p62 Dok (Phospho Tyr398) Cell-Based Colorimetric ELISA Kit
-KA1559C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
Dok-1 Rabbit pAb
YT1393
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Primary Antibodies
Dok-1 (Phospho Tyr398) Rabbit pAb
YP0523
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Primary Antibodies
Dok-1 (Phospho Tyr362) Rabbit pAb
YP0084
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ELISA Kits
Total p62 Dok Cell-Based Colorimetric ELISA Kit
KA4212C
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ELISA Kits
p62 Dok (Phospho Tyr398) Cell-Based Colorimetric ELISA Kit
KA1559C
预览→
ELISA Kits
p62 Dok (Phospho Tyr362) Cell-Based Colorimetric ELISA Kit
KA1558C
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抗原&靶点信息
基因名称:
DOK1
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别名:
Docking protein 1 ;
Downstream of tyrosine kinase 1 ;
p62 ;
dok ;
pp62 ;
Downstream of tyrosine kinase 1 ;
p62 ;
dok ;
pp62 ;
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背景:
domain:The PTB domain mediates receptor interaction. ,function:DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. ,PTM:Constitutively tyrosine-phosphorylated. ,PTM:Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. ,similarity:Belongs to the DOK family. Type A subfamily. ,similarity:Contains 1 IRS-type PTB domain. ,similarity:Contains 1 PH domain. ,subunit:Interacts with ABL (By similarity) . Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. ,tissue specificity:Expressed in pancreas , heart , leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. ,
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功能:
cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , intracellular signaling cascade , protein kinase cascade , small GTPase mediated signal transduction , Ras protein signal transduction ,
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细胞定位:
[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm , perinuclear region.
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