MAP3K5

Mitogen-activated protein kinase kinase kinase 5 ;
Apoptosis signal-regulating kinase 1 ;
ASK-1 ;
MAPK/ERK kinase kinase 5 ;
MEK kinase 5 ;
MEKK 5 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838 , inhibited by phosphorylation at Ser-966 and Ser-1033. Binds to , and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation on Thr-838. ,function:Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6 , which in turn activate the JNK and p38 MAP kinases , respectively. Overexpression induces apoptotic cell death. ,induction:By TNF-alpha. Inhibited by HIV-1 Nef. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L. ,tissue specificity:Abundantly expressed in heart and pancreas. ,

MAPKKK cascade , activation of MAPK activity , regulation of protein amino acid phosphorylation , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , apoptosis , induction of apoptosis ,intracellular signaling cascade , protein kinase cascade , JNK cascade , activation of JUN kinase activity , cell death ,induction of apoptosis by extracellular signals , regulation of protein kinase cascade , regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death , death , phosphorylation ,regulation of phosphate metabolic process , stress-activated protein kinase signaling pathway , regulation of protein modification process , regulation of cellular protein metabolic process , cellular response to stress , positive regulation of kinase activity , regulation of phosphorylation , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , positive regulation of catalytic activity ,regulation of MAP kinase activity , positive regulation of MAP kinase activity , regulation of MAPKKK cascade , regulation of JUN kinase activity , positive regulation of JUN kinase activity , regulation of kinase activity , positive regulation of molecular function , regulation of protein kinase activity , positive regulation of protein kinase activity , regulation of JNK cascade , regulation of phosphorus metabolic process , regulation of transferase activity , positive regulation of transferase activity , regulation of stress-activated protein kinase signaling pathway , regulation of cellular response to stress ,

Cytoplasm . Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region.