catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. ,enzyme regulation:Activated by tyrosine phosphorylation in response to insulin and NGF. ,function:Involved in both the initiation and regulation of meiosis , mitosis , and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2) . Phosphorylates SPZ1 (By similarity) . Phosphorylates heat shock factor protein 4 (HSF4) . ,PTM:Dually phosphorylated on Thr-202 and Tyr-204 , which activates the enzyme. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with MORG1 (By similarity) . Binds to HIV-1 Nef. This interaction inhibits its kinase activity. Interacts with HSF4 and NISCH. ,
展开内容