详细信息
推荐稀释比
Reconstitute in sterile water for a stock solution
组成
Supplied as solution form in PBS pH 7.5./ Lyophilized from PBS pH 7.5.
来源
E.coli
纯度
>90% as determined by SDS-PAGE
储存
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
抗原&靶点信息
序列:
A DNA sequence encoding the human IL18(Tyr37-Asp193) was fused with the C-terminal His Tag
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别名:
IGIF, IL1F4
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细胞定位:
Cytoplasm . Secreted . The precursor is cytosolic (PubMed:33883744). In response to inflammasome-activating signals, cleaved and secreted (PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059). .
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信号通路
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway
Human Diseases >> Immune disease >> Rheumatoid arthritis
Human Diseases >> Immune disease >> Inflammatory bowel disease
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Environmental Information Processing >> Signaling molecules and interaction >> Viral protein interaction with cytokine and cytokine receptor
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