TERF1

Telomeric repeat-binding factor 1 ;
NIMA-interacting protein 2 ;
TTAGGG repeat-binding factor 1 ;
Telomeric protein Pin2/TRF1 ;

domain:The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules. ,function:Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity , telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. ,induction:Pin2 expression is tightly regulated during the cell cycle; levels are low in G1 and S phase and increase during G2 phase and mitosis. ,PTM:ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA. ,PTM:Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage. ,similarity:Contains 1 HTH myb-type DNA-binding domain. ,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle. ,subunit:Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM , TINF2 , TNKS1 , TNKS2 , PINX1 , NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1 , TERF2 , TINF2 , TERF2IP ACD and POT1. ,tissue specificity:Highly expressed and ubiquitous. Isoform Pin2 predominates. ,

cell cycle checkpoint , G2/M transition of mitotic cell cycle , M phase of mitotic cell cycle , mitotic cell cycle , M phase ,nuclear division , telomere maintenance , progressive alteration of chromatin during cell aging , replicative cell aging ,progressive alteration of chromatin during replicative cell aging , age-dependent telomere shortening , DNA metabolic process , DNA replication , regulation of DNA replication , RNA-dependent DNA replication , chromatin organization ,protein complex assembly , apoptosis , induction of apoptosis , activation of caspase activity , telomere maintenance via telomerase , cell cycle , mitosis , regulation of mitosis , mitotic cell cycle checkpoint , mitotic cell cycle spindle assembly checkpoint , regulation of mitotic cell cycle , aging , cell aging , negative regulation of DNA replication , cell death , negative regulation of biosynthetic process , negative regulation of macromolecule biosynthetic process , regulation of cell cycle process , negative regulation of macromolecule metabolic process , positive regulation of organelle organization ,negative regulation of organelle organization , telomere maintenance via telomere lengthening , telomere maintenance via telomere shortening , regulation of cell death , positive regulation of cell death , negative regulation of cell cycle process , positive regulation of peptidase activity , programmed cell death , induction of programmed cell death , death ,chromatin modification , cell cycle process , cell cycle phase , regulation of mitotic metaphase/anaphase transition ,regulation of microtubule polymerization or depolymerization , positive regulation of microtubule polymerization or depolymerization , regulation of microtubule polymerization , positive regulation of microtubule polymerization , negative regulation of cellular biosynthetic process , positive regulation of protein complex assembly , spindle checkpoint ,telomere organization , regulation of telomere maintenance , negative regulation of telomere maintenance , regulation of telomere maintenance via telomerase , negative regulation of telomere maintenance via telomerase , regulation of telomere maintenance via semi-conservative replication , negative regulation of telomere maintenance via semi-conservative replication , regulation of protein polymerization , positive regulation of protein polymerization , regulation of homeostatic process , negative regulation of homeostatic process , regulation of microtubule-based process ,regulation of organelle organization , regulation of chromosome organization , homeostatic process , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , positive regulation of catalytic activity , negative regulation of catalytic activity , regulation of protein complex assembly , positive regulation of caspase activity , regulation of caspase activity , macromolecular complex subunit organization , regulation of cellular component biogenesis , negative regulation of molecular function , positive regulation of molecular function , regulation of transcription , negative regulation of cell cycle , positive regulation of cell cycle , negative regulation of mitosis , positive regulation of mitosis , negative regulation of mitotic metaphase/anaphase transition , positive regulation of mitotic cell cycle , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , organelle fission , regulation of DNA metabolic process ,negative regulation of DNA metabolic process , negative regulation of cellular component organization , positive regulation of cellular component organization , negative regulation of nitrogen compound metabolic process , protein oligomerization , protein homooligomerization , chromosome organization , cell division , interphase , interphase of mitotic cell cycle , regulation of hydrolase activity , regulation of transferase activity , positive regulation of hydrolase activity ,negative regulation of transferase activity , regulation of cytoskeleton organization , positive regulation of cytoskeleton organization , regulation of cell cycle , regulation of nuclear division , negative regulation of nuclear division , positive regulation of nuclear division , regulation of telomerase activity , negative regulation of telomerase activity , regulation of peptidase activity , regulation of endopeptidase activity , anatomical structure homeostasis , macromolecular complex assembly , protein complex biogenesis , regulation of microtubule cytoskeleton organization ,

Nucleus. Cytoplasm , cytoskeleton , spindle. Chromosome , telomere. Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase , anaphase and telophase. Associates with the mitotic spindle.