Recombinant SARS-CoV-2 (Covid-19) NSP8
-YD2198
主要信息
Reactivity
Humanvirus
Applications
ELISA, ECL, Immunogold,
MW
24kD (Calculated)
24kD (Observed)
详细信息
推荐稀释比
Testing in progress
来源
E.coli
纯度
>90% as determined by SDS-PAGE
储存
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
理论分子量
24kD
实测条带
24kD
抗原&靶点信息
基因名称:
ORF1ab
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蛋白名称:
SARS-CoV 2 nsp8
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数据库链接:
| Organism | 基因 ID | SwissProt |
|---|---|---|
| Human | YP_009725304.1; |
背景:
Recombinant SARS-CoV-2 NSP8 is produced by E.coli expression system and the target gene encoding Ala1-Gln198 is expressed with N-His Tag
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功能:
Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers. Nsp8 was shown to have RNA-dependent RNA polymerase (RdRp) activity that could be involved in producing primers utilized by nsp12 which is normally accepted to be the RdRp for SARS-CoV.
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研究领域:
For research use only .Not for use in clinical diagnostic procedures.
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