This recombinant monoclonal antibody can detects endogenous levels of EGFR protein.

EGFR

Epidermal growth factor receptor

EGFR ;
ERBB ;
ERBB1 ;
HER1 ;
Epidermal growth factor receptor ;
Proto-oncogene c-ErbB-1 ;
Receptor tyrosine-protein kinase erbB-1 ;
EGFR nanobody ;

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq , Jun 2016] ,

Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,Disease:Defects in EGFR are associated with lung cancer [MIM:211980]. ,Function:Isoform 2/truncated isoform may act as an antagonist. ,Function:Receptor for EGF , but also for other members of the EGF family , as TGF-alpha , amphiregulin , betacellulin , heparin-binding EGF-like growth factor , GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin. ,miscellaneous:Binding of EGF to the receptor leads to dimerization , internalization of the EGF-receptor complex , induction of the tyrosine kinase activity , stimulation of cell DNA synthesis , and cell proliferation. ,online information:EGFR entry ,PTM:Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63' , but linkage through 'Lys-48' , 'Lys-11' and 'Lys-29' also occur. ,PTM:Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B , maybe indirectly. Interacts with PELP1. Binds MUC1. ,tissue specificity:Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. ,

Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF , translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546 , PubMed:17909029) . Endocytosed upon activation by ligand (PubMed:2790960 , PubMed:17182860 , PubMed:27153536 , PubMed:17909029) . Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055) . .; [Isoform 2]: Secreted.

>>EGFR tyrosine kinase inhibitor resistance ;
>>Endocrine resistance ;
>>MAPK signaling pathway ;
>>ErbB signaling pathway ;
>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>Calcium signaling pathway ;
>>HIF-1 signaling pathway ;
>>FoxO signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>PI3K-Akt signaling pathway ;
>>Focal adhesion ;
>>Adherens junction ;
>>Gap junction ;
>>JAK-STAT signaling pathway ;
>>Regulation of actin cytoskeleton ;
>>GnRH signaling pathway ;
>>Estrogen signaling pathway ;
>>Oxytocin signaling pathway ;
>>Relaxin signaling pathway ;
>>Parathyroid hormone synthesis , secretion and action ;
>>Cushing syndrome ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Shigellosis ;
>>Hepatitis C ;
>>Human cytomegalovirus infection ;
>>Human papillomavirus infection ;
>>Coronavirus disease - COVID-19 ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>MicroRNAs in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Colorectal cancer ;
>>Pancreatic cancer ;
>>Endometrial cancer ;
>>Glioma ;
>>Prostate cancer ;
>>Melanoma ;
>>Bladder cancer ;
>>Non-small cell lung cancer ;
>>Breast cancer ;
>>Hepatocellular carcinoma ;
>>Gastric cancer ;
>>Central carbon metabolism in cancer ;
>>Choline metabolism in cancer ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer