Recombinant SARS-CoV-2(Covid-19) PL-Pro
-YD2186
主要信息
Reactivity
Humanvirus
Applications
ELISA, ECL, Immunogold,
MW
38.59kDa (Calculated)
34kDa (Observed)
详细信息
推荐稀释比
Testing in progress
来源
E.coli
纯度
>90% as determined by SDS-PAGE
储存
Use a manual defrost freezer and avoid repeated freeze thaw cycles.
Store at 2 to 8 °C for one week .
Store at -20 to -80 °C for twelve months from the date of receipt.
理论分子量
38.59kDa
实测条带
34kDa
抗原&靶点信息
基因名称:
ORF1ab
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蛋白名称:
nsp3,PL-PRO,Papain-like proteinase,Peptidase C16 domain
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数据库链接:
| Organism | 基因 ID | SwissProt |
|---|---|---|
| Human | QHD43415.1; |
背景:
Recombinant SARS-CoV-2 PL-Pro is produced by E.coli expression system and the target gene encoding Glu1564-IIe1877 is expressed with N-His Tag
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功能:
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.
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研究领域:
For research use only .Not for use in clinical diagnostic procedures.
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