NPM1 NPM

NPM1 ;
NPM ;
Nucleophosmin ;
NPM ;
Nucleolar phosphoprotein B23 ;
Nucleolar protein NO38 ;
Numatrin

disease:A chromosomal aberration involving NPM1 is a cause of myelodysplastic syndrome (MDS) . Translocation t (3;5) (q25.1;q34) with MLF1. ,disease:A chromosomal aberration involving NPM1 is found in a form of acute promyelocytic leukemia. Translocation t (5;17) (q32;q11) with RARA. ,disease:A chromosomal aberration involving NPM1 is found in a form of non-Hodgkin lymphoma. Translocation t (2;5) (p23;q35) with ALK. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. ,disease:Defects in NPM1 are associated with acute myelogenous leukemia (AML) . Mutations in exon 12 affecting the C-terminus of the protein are associated with an aberrant cytoplasmic location. ,function:Involved in diverse cellular processes such as ribosome biogenesis , centrosome duplication , protein chaperoning , histone assembly , cell proliferation , and regulation of tumor suppressors TP53/p53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3 , H2B and H4. ,PTM:Acetylated at C-terminal lysine residues , thereby increasing affinity to histones. ,PTM:ADP-ribosylated. ,PTM:Phosphorylated at Ser-4 by PLK1. Phosphorylated by CDK2 at Ser-125 and Thr-199. Phosphorylation at Thr-199 may trigger initiation of centrosome duplication. Phosphorylated by CDC2 at Thr-199 , Thr-219 , Thr-234 and Thr-237 during cell mitosis. When these four sites are phosphorated , RNA-binding activity seem to be abolished. May be phosphoryled at Ser-70 by NEK2. ,PTM:Sumoylated by ARF. ,similarity:Belongs to the nucleoplasmin family. ,subcellular location:Generally nucleolar , but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML) , but not with secondary AML. Can shuttle between cytoplasm and nucleus. ,subunit:Decamer formed by two pentameric rings associated in a head-to-head fashion. Disulfide-linked dimers under certain conditions. The SWAP complex consists of NPM1 , NCL , PARP1 and SWAP70 (By similarity) . Interacts with NSUN2. Interacts with hepatitis delta virus S-HDAg. ,

ribosome export from nucleus , ribosomal large subunit export from nucleus , ribosomal small subunit export from nucleus , microtubule cytoskeleton organization , DNA packaging , chromatin organization , chromatin assembly or disassembly , nucleosome assembly , RNA localization , RNA export from nucleus , rRNA export from nucleus , protein complex assembly , cell volume homeostasis , intracellular protein transport , nucleocytoplasmic transport , anti-apoptosis , cytoskeleton organization , microtubule-based process , cell cycle , centrosome cycle , aging , cell aging ,protein localization , positive regulation of cell proliferation , negative regulation of cell proliferation , regulation of cell size , positive regulation of biosynthetic process , regulation of cell cycle process , negative regulation of macromolecule metabolic process , positive regulation of organelle organization , negative regulation of organelle organization ,regulation of centrosome duplication , positive regulation of centrosome duplication , negative regulation of centrosome duplication , regulation of cell death , protein transport , nucleobase , nucleoside , nucleotide and nucleic acid transport ,cell growth , regulation of phosphate metabolic process , cellular homeostasis , cell cycle process , ribonucleoprotein complex biogenesis , ribonucleoprotein complex assembly , microtubule organizing center organization , positive regulation of cellular biosynthetic process , chromatin assembly , regulation of cellular component size , regulation of microtubule-based process , regulation of organelle organization , negative regulation of RNA splicing , positive regulation of kinase activity , ribosome localization , establishment of ribosome localization , cellular protein localization ,cellular macromolecular complex subunit organization , cellular macromolecular complex assembly , nucleosome organization , growth , regulation of cell proliferation , ribosome biogenesis , ribosome assembly , ribosomal large subunit biogenesis , ribosomal small subunit biogenesis , regulation of phosphorylation , homeostatic process , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , positive regulation of DNA binding , regulation of RNA splicing ,regulation of DNA damage response , signal transduction by p53 class mediator , regulation of kinase activity ,macromolecular complex subunit organization , positive regulation of molecular function , establishment of protein localization , regulation of transcription , regulation of protein kinase activity , positive regulation of protein kinase activity , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , regulation of centrosome cycle , intracellular transport , regulation of nuclear mRNA splicing , via spliceosome , negative regulation of nuclear mRNA splicing , via spliceosome , nucleic acid transport , RNA transport , regulation of mRNA processing , negative regulation of mRNA processing , rRNA transport , regulation of transcription factor activity , positive regulation of transcription factor activity , positive regulation of NF-kappaB transcription factor activity , regulation of binding , positive regulation of binding , regulation of DNA binding , negative regulation of cellular component organization , positive regulation of cellular component organization , nuclear export , nuclear transport , negative regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , establishment of RNA localization ,regulation of RNA metabolic process , negative regulation of RNA metabolic process , protein oligomerization ,chromosome organization , centrosome organization , regulation of transferase activity , positive regulation of transferase activity , regulation of cytoskeleton organization , organelle localization , establishment of organelle localization , regulation of cell cycle , negative regulation of cell death , macromolecular complex assembly , protein-DNA complex assembly , protein complex biogenesis , regulation of microtubule cytoskeleton organization , cellular macromolecule localization , regulation of cellular response to stress ,

Nucleus , nucleolus . Nucleus , nucleoplasm . Cytoplasm , cytoskeleton , microtubule organizing center , centrosome . Generally nucleolar , but is translocated to the nucleoplasm in case of serum starvation or treatment with anticancer drugs. Has been found in the cytoplasm in patients with primary acute myelogenous leukemia (AML) , but not with secondary AML. Can shuttle between cytoplasm and nucleus. Co- localizes with the methylated form of RPS10 in the granular component (GC) region of the nucleolus. Colocalized with nucleolin and APEX1 in nucleoli. Isoform 1 of NEK2 is required for its localization to the centrosome during mitosis.