ZC3HC1

Nuclear-interacting partner of ALK ;
Nuclear-interacting partner of anaplastic lymphoma kinase ;
hNIPA ;
Zinc finger C3HC-type protein 1 ;

caution:Reported to contain a F-box domain (PubMed:16009132) . Such domain is however not predicted by any detection method. ,developmental stage:Weakly expressed in G0/G1 phases , abundant during S and G2/M phases , and strongly decreases thereafter. ,domain:The F-box-like region is required for the interaction with SKP1A. ,function:Essential component of an SCF-type E3 ligase complex , SCF (NIPA) , a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1) . Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF (NIPA) complex , restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry. May have an antiapoptotic role in NPM-ALK-mediated signaling events. ,pathway:Protein modification; protein ubiquitination. ,PTM:Phosphorylated. Phosphorylated on Ser residues at G2/M phase , but not during S and G0 phases. May also be weakly phosphorylated on Tyr residues. Ser-354 phosphorylation , a major site during the course of cell-cycle-dedendent phosphorylation , results in its dissociation from the SCF (NIPA) complex , thereby preventing CCNB1 degradation leading to mitotic entry. ,similarity:Contains 1 C3HC-type zinc finger. ,subunit:Interacts with the NPM-ALK fusion protein in a tyrosine phosphorylation-dependent manner. Interacts with SKP1. Component of a SCF (NIPA) E3 complex with SKP1A , RBX1 and CUL1 when not phosphorylated on Ser-354. Interacts with CCNB1. ,tissue specificity:Widely expressed. Highly expressed in heart , skeletal muscle and testis. Expressed in brain , placenta , lung , kidney , liver , pancreas , spleen , thymus , prostate , ovary small intestine and colon. Weakly or not expressed in leukocytes. ,

M phase of mitotic cell cycle , mitotic cell cycle , M phase , nuclear division , proteolysis , anti-apoptosis , cell cycle , mitosis ,macromolecule catabolic process , regulation of cell death , modification-dependent protein catabolic process , cell cycle process , cell cycle phase , protein catabolic process , regulation of apoptosis , negative regulation of apoptosis ,regulation of programmed cell death , negative regulation of programmed cell death , modification-dependent macromolecule catabolic process , cellular protein catabolic process , cellular macromolecule catabolic process , organelle fission , cell division , proteolysis involved in cellular protein catabolic process , negative regulation of cell death ,

Nucleus .