CDK5 (Phospho Tyr15) Cell-Based Colorimetric ELISA Kit
-KA1512C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
CDK5 Rabbit pAb
YT0835
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Primary Antibodies
CDK5 (Phospho Tyr15) Rabbit pAb
YP0380
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ELISA Kits
Total CDK5 Cell-Based Colorimetric ELISA Kit
KA4037C
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ELISA Kits
CDK5 (Phospho Tyr15) Cell-Based Colorimetric ELISA Kit
KA1512C
预览→
抗原&靶点信息
基因名称:
CDK5 CDKN5
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蛋白名称:
Cyclin-dependent kinase 5
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别名:
Cyclin-dependent kinase 5 ;
Cell division protein kinase 5 ;
Serine/threonine-protein kinase PSSALRE ;
Tau protein kinase II catalytic subunit ;
TPKII catalytic subunit ;
Cell division protein kinase 5 ;
Serine/threonine-protein kinase PSSALRE ;
Tau protein kinase II catalytic subunit ;
TPKII catalytic subunit ;
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背景:
cyclin dependent kinase 5 (CDK5) Homo sapiens This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family , the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein , which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons , functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization , endocytosis and exocytosis , and apoptosis. In humans , an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq , May 2015] ,
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,Function:Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1 , tau , MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:In axonal growth cone with extension to the peripheral lamellipodia. ,subunit:Heterodimer of a catalytic subunit and a regulatory subunit (p35) . Found in a trimolecular complex with CABLES1 and ABL1. Interacts with CABLES1 (By similarity) . Interacts with AATK. ,
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细胞定位:
[Isoform 1]: Cytoplasm . Nucleus . Cell membrane ; Peripheral membrane protein. Perikaryon. Cell projection , lamellipodium . Cell projection , growth cone . Cell junction , synapse , postsynaptic density . Cell junction , synapse . In axonal growth cone with extension to the peripheral lamellipodia (By similarity) . Under neurotoxic stress and neuronal injury conditions , CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25 , when in complex with CDK5 , leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells , and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39) , p35 phosphorylation releases this attachment and activates CDK5. .; [Isoform 2]: Nucleus.
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