CD40

Tumor necrosis factor receptor superfamily member 5 ;
B-cell surface antigen CD40 ;
Bp50 ;
CD40L receptor ;
CDw40 ;
CD antigen CD40 ;

alternative products:Additional isoforms seem to exist ,disease:Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) [MIM:606843]. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching , one of the final differentiation steps in the humoral immune system , an inability to mount an antibody-specific immune response , and a lack of germinal center formation. ,function:Receptor for TNFSF5/CD40LG. ,online information:CD40 entry ,online information:CD40 mutation db ,similarity:Contains 4 TNFR-Cys repeats. ,subunit:Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1 , TRAF2 , TRAF3 , TRAF5 and TRAF6. ,tissue specificity:B-cells and in primary carcinomas. ,

regulation of DNA recombination , cell activation , regulation of cytokine production , positive regulation of cytokine production , regulation of immunoglobulin production , positive regulation of immune system process , regulation of leukocyte activation , positive regulation of leukocyte activation , regulation of immune effector process , regulation of production of molecular mediator of immune response , regulation of leukocyte mediated immunity , regulation of lymphocyte mediated immunity , regulation of B cell mediated immunity , immune response-regulating signal transduction , immune response-regulating cell surface receptor signaling pathway , regulation of adaptive immune response , regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , regulation of immunoglobulin mediated immune response , protein complex assembly , defense response , inflammatory response , cell surface receptor linked signal transduction , blood coagulation , hemostasis , cell proliferation , positive regulation of cell proliferation , response to wounding , positive regulation of signal transduction , positive regulation of macromolecule metabolic process , regulation of protein kinase cascade , positive regulation of cell communication , positive regulation of protein kinase cascade , platelet activation ,regulation of B cell proliferation , positive regulation of B cell proliferation , regulation of interleukin-12 production ,positive regulation of interleukin-12 production , regulation of protein localization , mononuclear cell proliferation ,regulation of mononuclear cell proliferation , positive regulation of mononuclear cell proliferation , wound healing , B cell proliferation , B cell activation , regulation of cell proliferation , regulation of I-kappaB kinase/NF-kappaB cascade ,positive regulation of I-kappaB kinase/NF-kappaB cascade , macromolecular complex subunit organization , regulation of isotype switching , leukocyte activation , positive regulation of isotype switching , positive regulation of DNA recombination , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process ,lymphocyte activation , lymphocyte proliferation , regulation of isotype switching to IgG isotypes , positive regulation of isotype switching to IgG isotypes , regulation of lymphocyte proliferation , positive regulation of lymphocyte proliferation , regulation of protein secretion , coagulation , regulation of B cell activation , regulation of cell activation ,positive regulation of cell activation , positive regulation of B cell activation , regulation of body fluid levels , regulation of immunoglobulin secretion , regulation of secretion , regulation of DNA metabolic process , positive regulation of DNA metabolic process , positive regulation of nitrogen compound metabolic process , regulation of protein transport ,positive regulation of multicellular organismal process , regulation of lymphocyte activation , positive regulation of lymphocyte activation , regulation of cellular localization , macromolecular complex assembly , regulation of establishment of protein localization , protein complex biogenesis , leukocyte proliferation , regulation of leukocyte proliferation , positive regulation of leukocyte proliferation ,

[Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.