MAP3K7

Mitogen-activated protein kinase kinase kinase 7 ;
Transforming growth factor-beta-activated kinase 1 ;
TGF-beta-activated kinase 1 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,function:Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF-kappa-B activation and the p38 MAPK pathway. ,PTM:Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation. Dephosphorylation at Thr-187 by PP2A and PPP6C leads to inactivation. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its' repressed activity. ,

MAPKKK cascade , angiogenesis , blood vessel development , regulation of cytokine production , positive regulation of cytokine production , embryonic epithelial tube formation , neural tube formation , vasculature development ,morphogenesis of an epithelium , activation of immune response , immune response-activating cell surface receptor signaling pathway , positive regulation of immune system process , regulation of leukocyte activation , positive regulation of leukocyte activation , regulation of immune effector process , positive regulation of immune effector process , regulation of production of molecular mediator of immune response , positive regulation of production of molecular mediator of immune response , regulation of leukocyte mediated immunity , positive regulation of leukocyte mediated immunity , regulation of lymphocyte mediated immunity , positive regulation of lymphocyte mediated immunity ,regulation of T cell mediated immunity , positive regulation of T cell mediated immunity , regulation of cytokine production during immune response , positive regulation of cytokine production during immune response , regulation of T cell cytokine production , positive regulation of T cell cytokine production , immune response-activating signal transduction , immune response-regulating signal transduction , immune response-regulating cell surface receptor signaling pathway , regulation of adaptive immune response , positive regulation of adaptive immune response ,regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway , transforming growth factor beta receptor signaling pathway , intracellular signaling cascade ,protein kinase cascade , I-kappaB kinase/NF-kappaB cascade , activation of NF-kappaB-inducing kinase activity , I-kappaB phosphorylation , embryonic development ending in birth or egg hatching , positive regulation of signal transduction , regulation of protein kinase cascade , positive regulation of cell communication , positive regulation of protein kinase cascade , regulation of cell death , phosphorylation , morphogenesis of embryonic epithelium , regulation of phosphate metabolic process , neural tube development , activation of protein kinase activity , regulation of interleukin-2 production , positive regulation of interleukin-2 production , positive regulation of kinase activity , tube lumen formation , tube morphogenesis , tube development , regulation of phosphorylation , regulation of apoptosis ,chordate embryonic development , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , regulation of I-kappaB kinase/NF-kappaB cascade , positive regulation of I-kappaB kinase/NF-kappaB cascade , regulation of MAPKKK cascade , positive regulation of MAPKKK cascade , regulation of kinase activity , positive regulation of molecular function , regulation of protein kinase activity , positive regulation of protein kinase activity , regulation of JNK cascade , positive regulation of JNK cascade ,blood vessel morphogenesis , positive regulation of response to stimulus , embryonic morphogenesis , tissue morphogenesis , positive regulation of immune response , antigen receptor-mediated signaling pathway , T cell receptor signaling pathway , regulation of T cell activation , regulation of cell activation , positive regulation of cell activation ,positive regulation of T cell activation , regulation of phosphorus metabolic process , positive regulation of multicellular organismal process , regulation of lymphocyte activation , positive regulation of lymphocyte activation , regulation of transferase activity , positive regulation of transferase activity , epithelium development , negative regulation of cell death , epithelial tube morphogenesis , regulation of stress-activated protein kinase signaling pathway , positive regulation of stress-activated protein kinase signaling pathway , regulation of cellular response to stress ,

Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Although the majority of MAP3K7/TAK1 is found in the cytosol , when complexed with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2 , it is also localized at the cell membrane.