function:Probably involved in connections of major cytoskeletal structures to the plasma membrane. ,PTM:Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures. ,similarity:Contains 1 FERM domain. ,subcellular location:Phosphorylated form is enriched in microvilli-like structures at apical membrane. ,subunit:In resting T-cells , part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity) . Binds SLC9A3R1. ,tissue specificity:In all tissues and cultured cells studied. ,
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm , cytoskeleton . Apical cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection , microvillus membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection , microvillus . Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity) . Localizes at the uropods of T lymphoblasts. .