IL4R

Interleukin-4 receptor subunit alpha ;
IL-4 receptor subunit alpha ;
IL-4R subunit alpha ;
IL-4R-alpha ;
IL-4RA ;
CD antigen CD124 ;
[Cleaved into: Soluble interleukin-4 receptor subunit alpha ;
Soluble IL-4 receptor subunit alpha ;
Soluble IL-4R-alpha ;
sIL4Ralpha/prot ;
IL-4-binding protein ;
IL4-BP ;
]

domain:Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM) . This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. ,domain:The box 1 motif is required for JAK interaction and/or activation. ,domain:The extracellular domain represents the IL4 binding protein (IL4BP) . ,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. ,function:Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and , chemokine and mucus production at sites of allergic inflammmation. In certain cell types , can signal through activation of insulin receptor substrates , IRS1/IRS2. ,function:Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. ,online information:The Singapore human mutation and polymorphism database ,polymorphism:Allelic variants in IL4RA are associated with a susceptibility to atopy , an immunological condition that can lead to clinical symptoms such as allergic rhinitis , sinusitis , asthma and eczema. ,PTM:On IL4 binding , phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues , Tyr-575 , Tyr-603 or Tyr-631 , is required for STAT6-induced gene induction. ,PTM:The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase. ,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily. ,similarity:Contains 1 fibronectin type-III domain. ,subunit:The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain , in immune cells , creates a type I receptor and , in non-immune cells , of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3 (By similarity) . Interacts with the SH2-containing phosphatases , PTPN6/SHIP1 , PTPN11/SHIP2 and INPP5D/SHIP (By similarity) . Interacts with JAK1 through a Box 1-containing region. In Th1 cells , binds the N-terminal 50 amino acids of SOCS5 , which inhibits JAK1 interaction , STAT6 activation and Th2 cell differentiation. SOCS5 interaction is independent of tyrosine phosphorylation. ,tissue specificity:Both isoform 1 and isoform 2 are highly expressed in activated T-cells. ,

negative regulation of immune system process , positive regulation of immune system process , regulation of leukocyte activation , negative regulation of leukocyte activation , positive regulation of leukocyte activation , regulation of adaptive immune response , regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains , regulation of T-helper 1 type immune response , regulation of T-helper 2 type immune response , immune response , regulation of CD4-positive , alpha beta T cell differentiation ,negative regulation of CD4-positive , alpha beta T cell differentiation , positive regulation of CD4-positive , alpha beta T cell differentiation , regulation of T cell differentiation , negative regulation of T cell differentiation , positive regulation of T cell differentiation , negative regulation of cell differentiation , positive regulation of cell differentiation , regulation of lymphocyte differentiation , negative regulation of lymphocyte differentiation , positive regulation of lymphocyte differentiation , regulation of T-helper cell differentiation , negative regulation of T-helper cell differentiation , positive regulation of T-helper cell differentiation , regulation of T-helper 1 cell differentiation , negative regulation of T-helper 1 cell differentiation , regulation of T-helper 2 cell differentiation , positive regulation of T-helper 2 cell differentiation ,regulation of alpha-beta T cell activation , positive regulation of alpha-beta T cell activation , negative regulation of alpha-beta T cell activation , regulation of alpha-beta T cell differentiation , positive regulation of alpha-beta T cell differentiation , negative regulation of alpha-beta T cell differentiation , regulation of T cell activation , regulation of cell activation , negative regulation of cell activation , positive regulation of cell activation , negative regulation of T cell activation , positive regulation of T cell activation , positive regulation of developmental process , regulation of lymphocyte activation , negative regulation of lymphocyte activation , positive regulation of lymphocyte activation ,

Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.