IL13RA1

Interleukin-13 receptor subunit alpha-1 ;
IL-13 receptor subunit alpha-1 ;
IL-13R subunit alpha-1 ;
IL-13R-alpha-1 ;
IL-13RA1 ;
Cancer/testis antigen 19 ;
CT19 ;
CD antigen CD213a1 ;

domain:The box 1 motif is required for JAK interaction and/or activation. ,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. ,function:Binds IL13 with a low affinity. Together with IL4R-alpha can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling , but cannot replace the function of gamma C in allowing enhanced IL2 binding activity. ,similarity:Belongs to the type I cytokine receptor family. Type 5 subfamily. ,subunit:Interleukin 13 receptor is a complex of IL4R , IL13RA1 , and possibly other components. Interacts with TRAF3IP1. ,tissue specificity:Ubiquitous. Highest levels in heart , liver , skeletal muscle and ovary; lowest levels in brain , lung and kidney. Also found in B-cells , T-cells and endothelial cells. ,

regulation of immunoglobulin production , positive regulation of immunoglobulin production , positive regulation of immune system process , regulation of leukocyte activation , positive regulation of leukocyte activation , regulation of immune effector process , positive regulation of immune effector process , regulation of production of molecular mediator of immune response , positive regulation of production of molecular mediator of immune response , cell surface receptor linked signal transduction , positive regulation of cell proliferation , regulation of B cell proliferation ,positive regulation of B cell proliferation , regulation of mononuclear cell proliferation , positive regulation of mononuclear cell proliferation , regulation of cell proliferation , regulation of lymphocyte proliferation , positive regulation of lymphocyte proliferation , regulation of B cell activation , regulation of cell activation , positive regulation of cell activation , positive regulation of B cell activation , regulation of lymphocyte activation , positive regulation of lymphocyte activation , regulation of leukocyte proliferation , positive regulation of leukocyte proliferation ,

Membrane; Single-pass type I membrane protein.