HNRNPD

Heterogeneous nuclear ribonucleoprotein D0 ;
hnRNP D0 ;
AU-rich element RNA-binding protein 1 ;

function:Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. ,PTM:Arg-345 is dimethylated , probably to asymmetric dimethylarginine. ,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part. ,sequence caution:Several sequence conflicts. ,similarity:Contains 2 RRM (RNA recognition motif) domains. ,subcellular location:Component of ribonucleosomes. ,subunit:Part of a complex associated with the FOS mCRD domain and consisting of PABPC1 , PAIP1 , CSDE1/UNR and SYNCRIP. Interacts with IGF2BP2. ,

RNA splicing , via transesterification reactions , RNA splicing , via transesterification reactions with bulged adenosine as nucleophile , nuclear mRNA splicing , via spliceosome , transcription , regulation of transcription , DNA-dependent , RNA processing , mRNA processing , RNA catabolic process , mRNA catabolic process , RNA splicing , macromolecule catabolic process , posttranscriptional regulation of gene expression , mRNA metabolic process , regulation of RNA stability ,regulation of mRNA stability , RNA stabilization , cellular macromolecule catabolic process , regulation of transcription ,mRNA stabilization , regulation of RNA metabolic process ,

Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.