HNRNPK

Heterogeneous nuclear ribonucleoprotein K ;
hnRNP K ;
Transformation up-regulated nuclear protein ;
TUNP ;

function:One of the major pre-mRNA-binding proteins. Binds tenaciously to poly (C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs , particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly (C) single-stranded DNA. ,mass spectrometry: PubMed:11840567 ,PTM:Arg-296 and Arg-299 are dimethylated , probably to asymmetric dimethylarginine. ,similarity:Contains 1 KH domain. ,similarity:Contains 2 KH domains. ,similarity:Contains 3 KH domains. ,subcellular location:In case of ASFV infection , there is a shift in the localization which becomes predominantly nuclear. ,subunit:Interacts with RBM42 and ZIK1 (By similarity) . Identified in the spliceosome C complex , at least composed of AQR , ASCC3L1 , C19orf29 , CDC40 , CDC5L , CRNKL1 , DDX23 , DDX41 , DDX48 , DDX5 , DGCR14 , DHX35 , DHX38 , DHX8 , EFTUD2 , FRG1 , GPATC1 , HNRPA1 , HNRPA2B1 , HNRPA3 , HNRPC , HNRPF , HNRPH1 , HNRNPK , HNRPM , HNRPR , HNRPU , KIAA1160 , KIAA1604 , LSM2 , LSM3 , MAGOH , MORG1 , PABPC1 , PLRG1 , PNN , PPIE , PPIL1 , PPIL3 , PPWD1 , PRPF19 , PRPF4B , PRPF6 , PRPF8 , RALY , RBM22 , RBM8A , RBMX , SART1 , SF3A1 , SF3A2 , SF3A3 , SF3B1 , SF3B2 , SF3B3 , SFRS1 , SKIV2L2 , SNRPA1 , SNRPB , SNRPB2 , SNRPD1 , SNRPD2 , SNRPD3 , SNRPE , SNRPF , SNRPG , SNW1 , SRRM1 , SRRM2 , SYF2 , SYNCRIP , TFIP11 , THOC4 , U2AF1 , WDR57 , XAB2 and ZCCHC8. Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein. ,

RNA splicing , via transesterification reactions , RNA splicing , via transesterification reactions with bulged adenosine as nucleophile , nuclear mRNA splicing , via spliceosome , RNA processing , mRNA processing , RNA splicing , mRNA metabolic process ,

Cytoplasm . Nucleus , nucleoplasm . Cell projection , podosome . Recruited to p53/TP53-responsive promoters , in the presence of functional p53/TP53 (PubMed:16360036) . In case of ASFV infection , there is a shift in the localization which becomes predominantly nuclear (PubMed:18775702) .