AURKB

Aurora kinase B,Aurora B

Aurora kinase B ;
Aurora 1 ;
Aurora- and IPL1-like midbody-associated protein 1 ;
AIM-1 ;
Aurora/IPL1-related kinase 2 ;
ARK-2 ;
Aurora-related kinase 2 ;
STK-1 ;
Serine/threonine-protein kinase 12 ;
Serine/threonine-protein kinase 5 ;
Serine/threonine-protein kinase aurora-B ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,disease:Disruptive regulation of expression is a possibile mechanism of the perturbation of chromosomal integrity in cancer cells through its dominant-negative effect on cytokinesis. ,function:May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Component of the chromosomal passenger complex (CPC) , a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis. ,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalized with gamma tubulin in the mid-body. ,subunit:Interacts with TACC1. Associates with RACGAP1 during M phase. Component of the CPC at least composed of BIRC5/survivin CDCA8/borealin , INCENP and AURKB/Aurora-B. Interacts with CDCA1 and NDC80. Interacts with EVI5. ,tissue specificity:High level expression seen in the thymus. It is also expressed in the spleen , lung , testis , colon , placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase. ,

M phase of mitotic cell cycle , mitotic cell cycle , M phase , nuclear division , cytokinesis , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cell cycle , mitosis , protein localization ,phosphorylation , cell cycle process , cell cycle phase , protein localization to kinetochore , cellular protein localization ,organelle fission , cell division , cellular macromolecule localization ,

Nucleus . Chromosome . Chromosome , centromere . Chromosome , centromere , kinetochore . Cytoplasm , cytoskeleton , spindle . Midbody . Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:20929775) . Colocalized with gamma tubulin in the midbody (PubMed:17726514) . Proper localization of the active , Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC (PubMed:20605920) . Colocalized with SIRT2 during cytokinesis with the midbody (PubMed:17726514) . Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12 (PubMed:20929775) . .