SMAD3 MADH3

Mothers against decapentaplegic homolog 3 ;
MAD homolog 3 ;
Mad3 ;
Mothers against DPP homolog 3 ;
hMAD-3 ;
JV15-2 ;
SMAD family member 3 ;
SMAD 3 ;
Smad3 ;
hSMAD3 ;

disease:Defects in SMAD3 may be a cause of colorectal cancer (CRC) [MIM:114500]. ,domain:The MH2 domain is sufficient to carry protein nuclear export. ,function:Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) . ,PTM:Phosphorylated on serine by TGF-beta and activin type 1 receptor kinases. ,similarity:Belongs to the dwarfin/SMAD family. ,similarity:Contains 1 MH1 (MAD homology 1) domain. ,similarity:Contains 1 MH2 (MAD homology 2) domain. ,subcellular location:In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with Smad4. ,subunit:Interacts with HGS. Interacts with NEDD4L in response to TGF-beta. Interacts with TTRAP (By similarity) . Interacts with SARA (SMAD anchor for receptor activation) ; form trimers with another SMAD3 and the co-SMAD SMAD4. Interacts with JUN/FOS , vitamin D receptor , homeobox protein TGIF and TGIF2 , PEBP2-alpha C subunit , CREB-binding protein (CBP) , p300 , SKI , SNON , ATF2 , SMURF2 , AIP1 , DACH1 and TGFB1I1. Part of a complex consisting of AIP1 , ACVR2A , ACVR1B and SMAD3. Found in a complex with SMAD2 and TRIM33 upon addition of TGF-beta. Interacts with SMAD2 and TRIM33. Found in a complex with SMAD3 , Ran and XPO4. Interacts with XPO4. Interacts with LBXCOR1 and CORL2. ,

negative regulation of transcription from RNA polymerase II promoter , skeletal system development , ossification ,regulation of cell growth , osteoblast differentiation , response to hypoxia , formation of primary germ layer , mesoderm formation , cell activation , regulation of cytokine production , positive regulation of cytokine production , release of cytochrome c from mitochondria , regulation of cell-matrix adhesion , positive regulation of cell-matrix adhesion ,osteoblast development , transcription , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , RNA processing , protein complex assembly , apoptosis , induction of apoptosis , activation of caspase activity , immune response , mitochondrion organization , cell cycle , cell cycle arrest , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway , transforming growth factor beta receptor signaling pathway , SMAD protein complex assembly , regulation of mitotic cell cycle , gastrulation , mesoderm development , cell death , negative regulation of cell proliferation , regulation of cell size , activation of pro-apoptotic gene products , apoptotic mitochondrial changes , response to wounding , negative regulation of biosynthetic process , positive regulation of biosynthetic process , response to organic substance , regulation of specific transcription from RNA polymerase II promoter , positive regulation of specific transcription from RNA polymerase II promoter , negative regulation of specific transcription from RNA polymerase II promoter , positive regulation of macromolecule biosynthetic process , negative regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , negative regulation of macromolecule metabolic process , posttranscriptional regulation of gene expression , positive regulation of gene expression , negative regulation of gene expression , positive regulation of organelle organization , regulation of alkaline phosphatase activity , positive regulation of alkaline phosphatase activity , regulation of epithelial to mesenchymal transition , positive regulation of epithelial to mesenchymal transition , positive regulation of cell development , regulation of cell morphogenesis involved in differentiation , positive regulation of cell morphogenesis involved in differentiation , regulation of cell-substrate adhesion , positive regulation of cell-substrate adhesion ,regulation of phosphatase activity , positive regulation of phosphatase activity , regulation of cell death , positive regulation of cell death , positive regulation of peptidase activity , programmed cell death , induction of programmed cell death , viral reproduction , regulation of striated muscle tissue development , death , posttranscriptional gene silencing ,gene silencing , negative regulation of transcription , regulation of transforming growth factor beta receptor signaling pathway , virus-host interaction , evasion of host defenses by virus , regulation of phosphate metabolic process , cell cycle process , viral reproductive process , regulation of cell morphogenesis , regulation of cell adhesion , regulation of ossification , negative regulation of cell growth , regulation of cell migration , positive regulation of cell migration ,regulation of bone mineralization , positive regulation of bone mineralization , gene silencing by RNA , dsRNA fragmentation , primary microRNA processing , negative regulation of cellular biosynthetic process , positive regulation of cellular biosynthetic process , regulation of response to external stimulus , positive regulation of response to external stimulus , regulation of actin filament bundle formation , positive regulation of actin filament bundle formation ,regulation of intracellular transport , positive regulation of intracellular transport , regulation of cellular component size ,negative regulation of gene-specific transcription , regulation of gene-specific transcription , regulation of interleukin-1 beta production , regulation of interleukin-1 production , positive regulation of interleukin-1 beta production , positive regulation of interleukin-1 production , regulation of protein localization , regulation of transforming growth factor-beta2 production , regulation of transforming growth factor-beta3 production , positive regulation of transforming growth factor-beta3 production , regulation of actin cytoskeleton organization , regulation of actin filament-based process ,regulation of organelle organization , regulation of intracellular protein transport , cell junction organization , ncRNA processing , cellular macromolecular complex subunit organization , cellular macromolecular complex assembly ,posttranscriptional gene silencing by RNA , gene silencing by miRNA , gene silencing by miRNA , production of miRNAs ,regulation of dephosphorylation , regulation of growth , regulation of locomotion , positive regulation of locomotion ,regulation of gene expression , epigenetic , wound healing , T cell activation , regulation of cell proliferation , regulation of protein import into nucleus , positive regulation of protein import into nucleus , regulation of apoptosis , regulation of transcription factor import into nucleus , positive regulation of transcription factor import into nucleus , positive regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , positive regulation of gene-specific transcription , positive regulation of caspase activity , regulation of caspase activity ,response to dsRNA , cellular protein complex assembly , macromolecular complex subunit organization , regulation of cellular component biogenesis , positive regulation of molecular function , avoidance of host defenses , evasion or tolerance of host defenses , cell-cell junction organization , leukocyte activation , regulation of transcription , negative regulation of cell differentiation , positive regulation of cell differentiation , regulation of osteoblast differentiation ,negative regulation of osteoblast differentiation , positive regulation of ossification , positive regulation of cell adhesion ,negative regulation of cell cycle , negative regulation of cell size , negative regulation of transcription , DNA-dependent ,positive regulation of transcription , DNA-dependent , negative regulation of growth , negative regulation of mitotic cell cycle , negative regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , lymphocyte activation , regulation of nucleocytoplasmic transport , positive regulation of nucleocytoplasmic transport , mesoderm morphogenesis , paraxial mesoderm development , paraxial mesoderm morphogenesis , positive regulation of behavior , positive regulation of response to stimulus , embryonic morphogenesis , regulation of muscle development , tissue morphogenesis , regulation of epithelial cell proliferation , regulation of behavior , regulation of chemotaxis , positive regulation of chemotaxis , regulation of positive chemotaxis , positive regulation of positive chemotaxis , positive regulation of transport , positive regulation of developmental process , regulation of binding , positive regulation of cellular component organization , negative regulation of nitrogen compound metabolic process , positive regulation of nitrogen compound metabolic process ,regulation of phosphorus metabolic process , positive regulation of protein transport , regulation of protein transport ,positive regulation of multicellular organismal process , regulation of RNA metabolic process , negative regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of cell motion , positive regulation of cell motion , regulation of hydrolase activity , positive regulation of hydrolase activity , regulation of stress fiber formation ,regulation of cytoskeleton organization , positive regulation of cytoskeleton organization , positive regulation of stress fiber formation , regulation of cell cycle , avoidance of defenses of other organism during symbiotic interaction , evasion or tolerance of defenses of other organism during symbiotic interaction , regulation of focal adhesion formation ,positive regulation of focal adhesion formation , response to defenses of other organism during symbiotic interaction ,response to host defenses , regulation of peptidase activity , regulation of endopeptidase activity , regulation of cell development , transdifferentiation , regulation of cellular localization , bone development , negative regulation of cell death , macromolecular complex assembly , regulation of biomineral formation , positive regulation of biomineral formation , regulation of establishment of protein localization , protein complex biogenesis , response to oxygen levels ,response to host ,

Cytoplasm . Nucleus . Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation , migrates to the nucleus when complexed with SMAD4 (PubMed:15799969 , PubMed:21145499) . Through the action of the phosphatase PPM1A , released from the SMAD2/SMAD4 complex , and exported out of the nucleus by interaction with RANBP1 (PubMed:16751101 , PubMed:19289081) . Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15601644) . MAPK-mediated phosphorylation appears to have no effect on nuclear import (PubMed:19218245) . PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236) . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm of the inner cell mass at the blastocyst stage (By similarity) . .