Amino acid: 135-239, with his-MBP tag.

PPARA

PPAR a protein

Peroxisome proliferator-activated receptor alpha ;
PPAR-alpha ;
Nuclear receptor subfamily 1 group C member 1 ;

function:Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids.,online information:Peroxisome proliferator-activated receptor entry,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Heterodimer with the retinoid X receptor. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Also interacts with PPARBP coactivator in vitro. Interacts with AKAP13.,tissue specificity:Skeletal muscle, liver, heart and kidney.,

negative regulation of transcription from RNA polymerase II promoter, response to hypoxia, circulatory system process, transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, fatty acid metabolic process, lipid transport, ectoderm development, blood circulation, regulation of blood pressure, epidermis development, response to wounding, response to endogenous stimulus, response to hormone stimulus, negative regulation of biosynthetic process, positive regulation of biosynthetic process, regulation of catabolic process, positive regulation of catabolic process, response to extracellular stimulus, response to organic substance, regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter, positive regulation of macromolecule biosynthetic process, negative regulation of macromolecule biosynthetic process, regulation of cellular ketone metabolic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, positive regulation of gene expression, negative regulation of gene expression, regulation of foam cell differentiation, negative regulation of foam cell differentiation, regulation of receptor biosynthetic process, negative regulation of receptor biosynthetic process,lipid localization, regulation of lipid storage, regulation of cholesterol storage, negative regulation of cholesterol storage, negative regulation of lipid storage, regulation of sequestering of triglyceride, negative regulation of sequestering of triglyceride, monocarboxylic acid transport, organic acid transport, fatty acid transport, negative regulation of transcription, regulation of lipid metabolic process, regulation of fatty acid metabolic process, negative regulation of cellular biosynthetic process, positive regulation of cellular biosynthetic process, regulation of cellular catabolic process, positive regulation of cellular catabolic process, response to nutrient levels, regulation of fatty acid beta-oxidation, positive regulation of fatty acid beta-oxidation, regulation of response to food, negative regulation of response to food, regulation of appetite, negative regulation of appetite, regulation of response to external stimulus,negative regulation of response to external stimulus, regulation of response to extracellular stimulus, negative regulation of response to extracellular stimulus, regulation of response to nutrient levels, negative regulation of response to nutrient levels, negative regulation of gene-specific transcription, regulation of gene-specific transcription,RNA biosynthetic process, response to insulin stimulus, wound healing, lipoprotein metabolic process, response to peptide hormone stimulus, regulation of transcription, negative regulation of cell differentiation, negative regulation of blood pressure, positive regulation of lipid metabolic process, negative regulation of transcription, DNA-dependent,positive regulation of transcription, DNA-dependent, positive regulation of fatty acid metabolic process, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of fatty acid oxidation, positive regulation of fatty acid oxidation, carboxylic acid transport, negative regulation of response to stimulus, regulation of lipid catabolic process,positive regulation of lipid catabolic process, negative regulation of nitrogen compound metabolic process, positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, positive regulation of RNA metabolic process, response to oxygen levels,

Nucleus.

Skeletal muscle, liver, heart and kidney. Expressed in monocytes (PubMed:28167758).