IRAK1

Interleukin-1 receptor-associated kinase 1 ;
IRAK-1 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,function:Binds to the IL-1 type I receptor following IL-1 engagement , triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower , more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated , IRAK1 recruits the adapter protein PELI1. ,PTM:Autophosphorylated or is transphosphorylated by IRAK4 following recruitment to the IL-1RI. In the case of isoform 1 , this is linked to ubiquitination and degradation. ,similarity:Belongs to the protein kinase superfamily. ,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1. Interacts with IRAK1BP1. ,tissue specificity:Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined , with isoform 1 being more strongly expressed than isoform 2. ,

regulation of cytokine-mediated signaling pathway , activation of innate immune response , pattern recognition receptor signaling pathway , toll-like receptor signaling pathway , response to molecule of bacterial origin , activation of immune response , positive regulation of immune system process , MyD88-dependent toll-like receptor signaling pathway , immune response-activating signal transduction , innate immune response-activating signal transduction ,immune response-regulating signal transduction , protein complex assembly , protein amino acid phosphorylation ,phosphorus metabolic process , phosphate metabolic process , anti-apoptosis , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein serine/threonine kinase signaling pathway , intracellular signaling cascade , protein kinase cascade , I-kappaB kinase/NF-kappaB cascade , activation of NF-kappaB-inducing kinase activity , response to bacterium , positive regulation of biosynthetic process , response to organic substance , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , regulation of cell death , phosphorylation ,regulation of phosphate metabolic process , cytokine-mediated signaling pathway , positive regulation of cellular biosynthetic process , positive regulation of defense response , lipopolysaccharide-mediated signaling pathway ,negative regulation of NF-kappaB transcription factor activity , activation of protein kinase activity , response to lipopolysaccharide , positive regulation of kinase activity , response to cytokine stimulus , toll-like receptor 2 signaling pathway , regulation of phosphorylation , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , positive regulation of DNA binding , negative regulation of DNA binding , negative regulation of transcription factor activity ,regulation of kinase activity , macromolecular complex subunit organization , negative regulation of molecular function ,positive regulation of molecular function , regulation of innate immune response , positive regulation of innate immune response , regulation of transcription , regulation of protein kinase activity , positive regulation of protein kinase activity ,positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , protein amino acid autophosphorylation , positive regulation of response to stimulus , positive regulation of immune response , regulation of transcription factor activity , positive regulation of transcription factor activity ,positive regulation of NF-kappaB transcription factor activity , regulation of binding , positive regulation of binding ,negative regulation of binding , regulation of DNA binding , positive regulation of nitrogen compound metabolic process ,regulation of phosphorus metabolic process , protein oligomerization , regulation of transferase activity , positive regulation of transferase activity , negative regulation of cell death , macromolecular complex assembly , protein complex biogenesis , interleukin-1-mediated signaling pathway , response to interleukin-1 ,

Cytoplasm . Nucleus . Lipid droplet . Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity) . .