GRIA4

Glutamate receptor 4 ;
GluR-4 ;
GluR4 ;
AMPA-selective glutamate receptor 4 ;
GluR-D ;
Glutamate receptor ionotropic,AMPA 4 ;
GluA4 ;

function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change , leading to the opening of the cation channel , and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state , characterized by the presence of bound agonist. ,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. ,PTM:Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast , Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. ,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family. ,subunit:Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus. ,

ion transport , cell surface receptor linked signal transduction , glutamate signaling pathway , cell-cell signaling , synaptic transmission , positive regulation of cell communication , transmission of nerve impulse , regulation of neurological system process , positive regulation of neurological system process , regulation of system process , regulation of synaptic transmission , positive regulation of synaptic transmission , neurological system process , positive regulation of multicellular organismal process , regulation of synaptic transmission , glutamatergic , positive regulation of synaptic transmission , glutamatergic , regulation of transmission of nerve impulse , positive regulation of transmission of nerve impulse ,

Cell membrane; Multi-pass membrane protein. Cell junction , synapse , postsynaptic cell membrane; Multi-pass membrane protein. Cell projection , dendrite. Interaction with CNIH2 , CNIH3 and PRKCG promotes cell surface expression. .