详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS
来源
E.coli
纯度
SDS-PAGE >90%
储存
-20°C/6 month,-80°C for long storage
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
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Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
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Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
预览→
抗原&靶点信息
序列:
Amino acid: 264-465, with his-MBP tag.
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基因名称:
AKT3
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蛋白名称:
Akt3 protein
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别名:
RAC-gamma serine/threonine-protein kinase ;
Protein kinase Akt-3 ;
Protein kinase B gamma ;
PKB gamma ;
RAC-PK-gamma ;
STK-2 ;
Protein kinase Akt-3 ;
Protein kinase B gamma ;
PKB gamma ;
RAC-PK-gamma ;
STK-2 ;
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背景:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.,enzyme regulation:Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation.,function:IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation.,subunit:Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation.,tissue specificity:In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.,
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功能:
AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.
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细胞定位:
AKT3: Cytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation.
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组织表达:
In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
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信号通路
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Cell growth and death >> Apoptosis
Cellular Processes >> Cell growth and death >> Cellular senescence
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells
Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton
Organismal Systems >> Immune system >> Platelet activation
Organismal Systems >> Immune system >> Neutrophil extracellular trap formation
Organismal Systems >> Immune system >> Toll-like receptor signaling pathway
Organismal Systems >> Immune system >> T cell receptor signaling pathway
Organismal Systems >> Immune system >> B cell receptor signaling pathway
Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway
Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis
Organismal Systems >> Immune system >> Chemokine signaling pathway
Organismal Systems >> Endocrine system >> Insulin signaling pathway
Organismal Systems >> Endocrine system >> Glucagon signaling pathway
Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway
Organismal Systems >> Endocrine system >> Estrogen signaling pathway
Organismal Systems >> Endocrine system >> Prolactin signaling pathway
Organismal Systems >> Endocrine system >> Relaxin signaling pathway
Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action
Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway
Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes
Organismal Systems >> Nervous system >> Cholinergic synapse
Organismal Systems >> Nervous system >> Dopaminergic synapse
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Organismal Systems >> Development and regeneration >> Osteoclast differentiation
Organismal Systems >> Aging >> Longevity regulating pathway
Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: overview >> Central carbon metabolism in cancer
Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer
Human Diseases >> Cancer: specific types >> Colorectal cancer
Human Diseases >> Cancer: specific types >> Pancreatic cancer
Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Glioma
Human Diseases >> Cancer: specific types >> Acute myeloid leukemia
Human Diseases >> Cancer: specific types >> Chronic myeloid leukemia
Human Diseases >> Cancer: specific types >> Melanoma
Human Diseases >> Cancer: specific types >> Renal cell carcinoma
Human Diseases >> Cancer: specific types >> Prostate cancer
Human Diseases >> Cancer: specific types >> Endometrial cancer
Human Diseases >> Cancer: specific types >> Breast cancer
Human Diseases >> Cancer: specific types >> Small cell lung cancer
Human Diseases >> Cancer: specific types >> Non-small cell lung cancer
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Environmental Information Processing >> Signal transduction >> ErbB signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway
Environmental Information Processing >> Signal transduction >> VEGF signaling pathway
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway
Environmental Information Processing >> Signal transduction >> FoxO signaling pathway
Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway
Environmental Information Processing >> Signal transduction >> Sphingolipid signaling pathway
Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
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