ESR2 ESTRB NR3A2

ESR2 ;
ESTRB ;
NR3A2 ;
Estrogen receptor beta ;
ER-beta ;
Nuclear receptor subfamily 3 group A member 2

domain:Composed of three domains: a modulating N-terminal domain , a DNA-binding domain and a C-terminal steroid-binding domain. ,function:Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 , and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. ,online information:Estrogen receptor entry ,similarity:Belongs to the nuclear hormone receptor family. ,similarity:Belongs to the nuclear hormone receptor family. NR3 subfamily. ,similarity:Contains 1 nuclear receptor DNA-binding domain. ,subunit:Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA3 , NCOA5 and NCOA6 coactivators , leading to a strong increase of transcription of target genes. Interacts with PELP1 and UBE1C. Isoform beta-2/cx preferentially forms a hetereodimer with ESR1 rather than ESR2 and inhibits DNA-binding by ESR1. Interacts with AKAP13. Interacts with DNTTIP2. Interacts with isoform 4 of TXNRD1. ,tissue specificity:Isoform beta-1 is expressed in testis and ovary , and at a lower level in heart , brain , placenta , liver , skeletal muscle , spleen , thymus , prostate , colon , bone marrow , mammary gland and uterus. Also found in uterine bone , breast , and ovarian tumor cell lines , but not in colon and liver tumors. Isoform beta-2 is expressed in spleen , thymus , testis and ovary and at a lower level in skeletal muscle , prostate , colon , small intestine , leukocytes , bone marrow , mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis , and at a lower level in spleen , thymus , ovary , mammary gland and uterus. Isoform beta-5 is expressed in testis , placenta , skeletal muscle , spleen and leukocytes , and at a lower level in heart , lung , liver , kidney , pancreas , thymus , prostate , colon , small intestine , bone marrow , mammary gland and uterus. Not expressed in brain. ,

regulation of cell growth , behavioral fear response , neuron migration , behavioral defense response , transcription ,regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , anti-apoptosis , cell motion , defense response , intracellular signaling cascade , cell-cell signaling , behavior , learning or memory , negative regulation of cell proliferation , regulation of cell size , response to endogenous stimulus , response to hormone stimulus , positive regulation of biosynthetic process , response to organic substance , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , regulation of cell death , cell migration , negative regulation of cell growth , steroid hormone receptor signaling pathway , estrogen receptor signaling pathway , intracellular receptor-mediated signaling pathway , positive regulation of cellular biosynthetic process , regulation of cellular component size , regulation of gene-specific transcription , multicellular organismal response to stress , response to testosterone stimulus , regulation of growth ,regulation of cell proliferation , fear response , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of gene-specific transcription , regulation of neuron apoptosis , neuroprotection , regulation of transcription , negative regulation of cell size , regulation of survival gene product expression , positive regulation of survival gene product expression , positive regulation of transcription , DNA-dependent , negative regulation of growth , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , negative regulation of behavior , response to steroid hormone stimulus , negative regulation of response to stimulus , cell motility , regulation of epithelial cell proliferation , negative regulation of epithelial cell proliferation , regulation of behavior , neurological system process , cognition , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , localization of cell , negative regulation of cell death ,

Nucleus .