Amino acid: 58-178, with his-MBP tag.

MAP2K5

MEK5 protein

Dual specificity mitogen-activated protein kinase kinase 5 ;
MAP kinase kinase 5 ;
MAPKK 5 ;
MAPK/ERK kinase 5 ;
MEK 5 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates interactions with SQSTM1 and PARD6A.,function:Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis.,PTM:Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.,PTM:Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ.,tissue specificity:Expressed in many adult tissues. Abundant in heart and skeletal muscle.,

MAPKKK cascade, regulation of cell growth, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, intracellular signaling cascade, protein kinase cascade, heart development, positive regulation of cell proliferation, regulation of cell size, phosphorylation, positive regulation of cell growth, regulation of cellular component size, regulation of growth, regulation of cell proliferation, positive regulation of cell size, positive regulation of growth, regulation of epithelial cell proliferation, positive regulation of epithelial cell proliferation,

Expressed in many adult tissues. Abundant in heart and skeletal muscle.