EGFR

EGFR ;
ERBB ;
ERBB1 ;
HER1 ;
Epidermal growth factor receptor ;
Proto-oncogene c-ErbB-1 ;
Receptor tyrosine-protein kinase erbB-1

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,disease:Defects in EGFR are associated with lung cancer [MIM:211980]. ,function:Isoform 2/truncated isoform may act as an antagonist. ,function:Receptor for EGF , but also for other members of the EGF family , as TGF-alpha , amphiregulin , betacellulin , heparin-binding EGF-like growth factor , GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with C-SRC and CTNNB1/beta-catenin. ,miscellaneous:Binding of EGF to the receptor leads to dimerization , internalization of the EGF-receptor complex , induction of the tyrosine kinase activity , stimulation of cell DNA synthesis , and cell proliferation. ,online information:EGFR entry ,PTM:Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63' , but linkage through 'Lys-48' , 'Lys-11' and 'Lys-29' also occur. ,PTM:Phosphorylation of Ser-695 is partial and occurs only if Thr-693 is phosphorylated. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Binds RIPK1. CBL interacts with the autophosphorylated C-terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B , maybe indirectly. Interacts with PELP1. Binds MUC1. ,tissue specificity:Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers. ,

regulation of cyclin-dependent protein kinase activity , G1/S transition of mitotic cell cycle , MAPKKK cascade , activation of MAPKK activity , mitotic cell cycle , cell morphogenesis , skeletal system development , ossification , cell activation ,regulation of protein amino acid phosphorylation , translation , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , response to osmotic stress , response to oxidative stress , cell cycle ,cell adhesion , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway ,transmembrane receptor protein tyrosine kinase signaling pathway , epidermal growth factor receptor signaling pathway , activation of phospholipase C activity , intracellular signaling cascade , protein kinase cascade , regulation of mitotic cell cycle , sensory organ development , salivary gland development , salivary gland morphogenesis , circadian rhythm , protein localization , cell proliferation , positive regulation of cell proliferation , response to radiation , response to UV , response to light stimulus , response to abiotic stimulus , positive regulation of biosynthetic process , glial cell differentiation , response to organic substance , response to inorganic substance , response to metal ion , regulation of phospholipase activity , positive regulation of phospholipase activity , positive regulation of phosphorus metabolic process , positive regulation of cell communication , positive regulation of phospholipase C activity , regulation of cell death , astrocyte development , membrane organization , phosphorylation , cell-cell adhesion , regulation of phosphate metabolic process , calcium-mediated signaling , second-messenger-mediated signaling , glial cell development , cell cycle process , cell cycle phase , biological adhesion , gland morphogenesis , cell projection organization , neuron differentiation , regulation of cell migration , positive regulation of cell migration , neuron projection development ,positive regulation of cellular biosynthetic process , regulation of protein modification process , regulation of neurological system process , positive regulation of neurological system process , regulation of cyclin-dependent protein kinase activity during G1/S , positive regulation of cyclin-dependent protein kinase activity during G1/S ,activation of protein kinase activity , regulation of cellular protein metabolic process , regulation of phospholipase A2 activity , positive regulation of phospholipase A2 activity , activation of phospholipase A2 activity , multicellular organism reproduction , regulation of monooxygenase activity , cellular component morphogenesis , cell part morphogenesis ,positive regulation of kinase activity , response to lipid , cellular protein localization , exocrine system development ,regulation of locomotion , positive regulation of locomotion , gliogenesis , regulation of cell proliferation , regulation of phosphorylation , positive regulation of phosphorylation , ovulation cycle , regulation of apoptosis , activation of phospholipase A2 activity by calcium-mediated signaling , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity , regulation of kinase activity , tongue development , regulation of system process , positive regulation of molecular function , regulation of nitric oxide biosynthetic process , positive regulation of nitric oxide biosynthetic process , positive regulation of cyclin-dependent protein kinase activity , negative regulation of cell cycle , positive regulation of cell cycle , regulation of protein kinase activity , positive regulation of protein kinase activity , negative regulation of mitotic cell cycle , positive regulation of phosphate metabolic process ,protein amino acid autophosphorylation , astrocyte activation , rhythmic process , reproductive process in a multicellular organism , regulation of smooth muscle cell proliferation , positive regulation of smooth muscle cell proliferation , neuron development , astrocyte differentiation , gland development , neuron projection morphogenesis , cell projection morphogenesis , regulation of epithelial cell proliferation , positive regulation of epithelial cell proliferation , regulation of peptidyl-tyrosine phosphorylation , regulation of synaptic transmission , positive regulation of synaptic transmission ,regulation of nitric-oxide synthase activity , positive regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , protein insertion into membrane , positive regulation of multicellular organismal process , regulation of cell motion , positive regulation of cell motion , interphase , interphase of mitotic cell cycle ,regulation of hydrolase activity , regulation of transferase activity , regulation of oxidoreductase activity , positive regulation of hydrolase activity , positive regulation of transferase activity , response to calcium ion , localization within membrane , regulation of cell cycle , regulation of synaptic transmission , glutamatergic , positive regulation of synaptic transmission , glutamatergic , regulation of transmission of nerve impulse , positive regulation of transmission of nerve impulse , regulation of lipase activity , positive regulation of lipase activity , bone development , negative regulation of cell death , response to UV-A , cellular macromolecule localization ,

Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Endosome . Endosome membrane. Nucleus . In response to EGF , translocated from the cell membrane to the nucleus via Golgi and ER (PubMed:20674546 , PubMed:17909029) . Endocytosed upon activation by ligand (PubMed:2790960 , PubMed:17182860 , PubMed:27153536 , PubMed:17909029) . Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (PubMed:20551055) . .; [Isoform 2]: Secreted.