EPB49

Dematin ;
Erythrocyte membrane protein band 4.9 ;

domain:Consists of a large core fragment , the amino-terminal portion , and a small headpiece , the C-terminal portion. The headpiece can bind but cannot bundle actin filaments. ,domain:Contains at least two actin-binding sites , one in the headpiece domain and one in the amino-terminal portion. ,function:Actin-bundling protein. May function in mitogen-activated protein kinase pathway. ,PTM:Actin-bundling activity is abolished upon phosphorylation by cAMP-dependent protein kinase. ,PTM:The N-terminus is blocked. ,similarity:Belongs to the villin/gelsolin family. ,similarity:Contains 1 HP (headpiece) domain. ,subunit:Exists in solution as a trimer of two short isoforms and one long isoform linked by disulfide bonds (Probable) . Interacts with RASGRF2. ,tissue specificity:Heart , brain , lung , skeletal muscle , and kidney. ,

cytoskeleton organization , actin filament organization , regulation of actin polymerization or depolymerization , negative regulation of organelle organization , actin filament-based process , actin cytoskeleton organization , regulation of actin filament length , regulation of actin filament polymerization , regulation of actin filament depolymerization , negative regulation of actin filament depolymerization , negative regulation of actin filament polymerization , negative regulation of protein complex assembly , regulation of protein polymerization , negative regulation of protein polymerization ,regulation of cellular component size , regulation of actin cytoskeleton organization , regulation of actin filament-based process , regulation of organelle organization , negative regulation of protein complex disassembly , regulation of protein complex disassembly , regulation of protein complex assembly , regulation of cellular component biogenesis ,actin filament bundle formation , negative regulation of cellular component organization , regulation of cytoskeleton organization , negative regulation of cytoskeleton organization , actin filament capping ,

Cytoplasm. Cytoplasm , cytosol. Cytoplasm , perinuclear region . Cytoplasm , cytoskeleton. Cell membrane. Membrane . Endomembrane system. Cell projection . Localized at the spectrin-actin junction of erythrocyte plasma membrane. Localized to intracellular membranes and the cytoskeletal network. Localized at intracellular membrane-bounded organelle compartment in platelets that likely represent the dense tubular network membrane. Detected at the cell membrane and at the parasitophorous vacuole in malaria-infected erythrocytes at late stages of plasmodium berghei or falciparum development.