DAPK3 (Phospho Thr265) Cell-Based Colorimetric ELISA Kit
-KA1448C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
DAPK3 Rabbit pAb
YT1289
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Primary Antibodies
DAPK3 (Phospho Thr265) Rabbit pAb
YP0548
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ELISA Kits
Total DAPK3 Cell-Based Colorimetric ELISA Kit
KA4069C
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ELISA Kits
DAPK3 (Phospho Thr265) Cell-Based Colorimetric ELISA Kit
KA1448C
预览→
抗原&靶点信息
基因名称:
DAPK3
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别名:
Death-associated protein kinase 3 ;
DAP kinase 3 ;
DAP-like kinase ;
Dlk ;
MYPT1 kinase ;
Zipper-interacting protein kinase ;
ZIP-kinase ;
DAP kinase 3 ;
DAP-like kinase ;
Dlk ;
MYPT1 kinase ;
Zipper-interacting protein kinase ;
ZIP-kinase ;
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背景:
catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,function:Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subcellular location:Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity) . Associates to centromeres from prophase to anaphase. ,subunit:Homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. Also binds to DAXX and PAWR , possibly in a ternary complex which plays a role in caspase activation. Interacts with AATF and CDC5L. ,
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功能:
chromatin organization , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , apoptosis , induction of apoptosis , intracellular signaling cascade , protein kinase cascade , cell death ,regulation of cell death , positive regulation of cell death , programmed cell death , induction of programmed cell death ,death , phosphorylation , chromatin modification , neuron differentiation , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , chromosome organization ,
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细胞定位:
Nucleus . Cytoplasm . Predominantly localizes to the cytoplasm but can shuttle between the nucleus and cytoplasm; cytoplasmic localization is promoted by phosphorylation at Thr-299 and involves Rho/Rock signaling. .; [Isoform 1]: Nucleus . Cytoplasm .; [Isoform 2]: Nucleus . Cytoplasm .
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