CRYAB

Alpha-crystallin B chain ;
Alpha ;
B ;
-crystallin ;
Heat shock protein beta-5 ;
HspB5 ;
Renal carcinoma antigen NY-REN-27 ;
Rosenthal fiber component ;

disease:Crystallins do not turn over as the lens ages , providing ample opportunity for post-translational modifications or oxidations. These modifications may change crystallin solubility properties and favor senile cataract. ,disease:Defects in CRYAB are the cause of alpha-B crystallinopathy [MIM:608810]. Alpha-B crystallinopathy is a an autosomal dominant form of desmin-related myopathy (DRM) that results in weakness of the proximal and distal limb muscle (including neck , velopharynx , and trunk muscles) , signs of cardiomyopathy and cataract. Patients with progressive myopathy characterized by myofibrillar degeneration that commences at the Z-disk , have been described. Mutations truncate the essential C-terminal domain of the protein required for the chaperone function. ,disease:Seen as Rosenthal fiber protein in the brain tissue of patients with Alexander disease. ,function:May contribute to the transparency and refractive index of the lens. ,mass spectrometry: PubMed:10930324 ,mass spectrometry: PubMed:8175657 ,mass spectrometry:With 1 phosphate group PubMed:10930324 ,mass spectrometry:With 1 phosphate group PubMed:8175657 ,mass spectrometry:With 2 phosphate groups PubMed:8175657 ,similarity:Belongs to the small heat shock protein (HSP20) family. ,subunit:Aggregates with homologous proteins , including CRYAA and the small heat shock protein HSPB1 , to form large heteromeric complexes. Interacts with HSPBAP1 and TTN/titin. ,tissue specificity:Lens as well as other tissues. ,

MAPKKK cascade , microtubule cytoskeleton organization , response to reactive oxygen species , regulation of cell growth , eye development , muscle system process , monosaccharide metabolic process , glucose metabolic process ,protein folding , protein complex assembly , oxygen and reactive oxygen species metabolic process , anti-apoptosis ,muscle contraction , response to oxidative stress , cytoskeleton organization , microtubule-based process , intracellular signaling cascade , protein kinase cascade , sensory organ development , muscle organ development , aging , regulation of cell size , response to temperature stimulus , response to heat , response to abiotic stimulus , response to endogenous stimulus , response to hormone stimulus , response to organic substance , response to inorganic substance , regulation of cell death , hexose metabolic process , negative regulation of cell growth , stress-activated protein kinase signaling pathway , microtubule polymerization or depolymerization , response to estradiol stimulus ,regulation of intracellular transport , negative regulation of intracellular transport , regulation of cellular component size , cellular response to stress , regulation of growth , response to hydrogen peroxide , regulation of apoptosis ,camera-type eye development , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , response to estrogen stimulus , macromolecular complex subunit organization ,negative regulation of cell size , negative regulation of growth , response to steroid hormone stimulus , negative regulation of transport , protein oligomerization , protein homooligomerization , stress-activated MAPK cascade ,regulation of cellular localization , negative regulation of cell death , macromolecular complex assembly , protein complex biogenesis ,

Cytoplasm . Nucleus . Secreted . Lysosome . Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles (PubMed:19464326) . Localizes at the Z-bands and the intercalated disk in cardiomyocytes (PubMed:28493373) . Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059) . .