CXCR4

C-X-C chemokine receptor type 4 ;
CXC-R4 ;
CXCR-4 ;
FB22 ;
Fusin ;
HM89 ;
LCR1 ;
Leukocyte-derived seven transmembrane domain receptor ;
LESTR ;
NPYRL ;
Stromal cell-derived factor 1 receptor ;
SDF-1 receptor ;
CD antigen CD184 ;

alternative products:Additional isoforms seem to exist ,caution:Was originally (PubMed:8329116 and PubMed:8234909) thought to be a receptor for neuropeptide Y type 3 (NPY3R) (NPY3-R) . ,disease:Defects in CXCR4 are a cause of WHIM syndrome [MIM:193670]; also called warts , hypogammaglobulinemia , infections , and myelokathexis. WHIM syndrome is an immunodeficiency disease characterized by neutropenia , hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia , bone marrow aspirates from affected individuals contain abundant mature myeloid cells , a condition termed myelokathexis. ,domain:The amino-terminus is critical for ligand binding. Residues in all four extracellular regions contribute to HIV-1 coreceptor activity. ,function:Receptor for the C-X-C chemokine CXCL12/SDF-1. Transduces a signal by increasing the intracellular calcium ions level. Involved in haematopoiesis and in cardiac ventricular septum formation. Plays also an essential role in vascularization of the gastrointestinal tract , probably by regulating vascular branching and/or remodeling processes in endothelial cells. Could be involved in cerebellar development. In the CNS , could mediate hippocampal-neuron survival. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. ,online information:CXC chemokine receptors entry ,online information:CXCR4 entry ,online information:CXCR4 mutation db ,PTM:O- and N-glycosylated. Asn-11 is the principal site of N-glycosylation. There appears to be very little or no glycosylation on Asn-176. N-glycosylation masks coreceptor function in both X4 and R5 laboratory-adapted and primary HIV-1 strains through inhibiting interaction with their Env glycoproteins. The O-glycosylation chondroitin sulfate attachment does not affect interaction with CXCL12/SDF-1alpha nor its coreceptor activity. ,PTM:Sulfation on Tyr-21 is required for efficient binding of CXCL12/SDF-1alpha and promotes its dimerization. ,similarity:Belongs to the G-protein coupled receptor 1 family. ,subunit:Monomer. Can form dimers. Interacts with HIV-1 surface protein gp120 and Tat. ,tissue specificity:Expressed in numerous tissues , such as peripheral blood leukocytes , spleen , thymus , spinal cord , heart , placenta , lung , liver , skeletal muscle , kidney , pancreas , cerebellum , cerebral cortex and medulla (in microglia as well as in astrocytes) , brain microvascular , coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested. ,

MAPKKK cascade , activation of MAPK activity , cell morphogenesis , cell morphogenesis involved in differentiation ,angiogenesis , blood vessel development , patterning of blood vessels , response to hypoxia , ameboidal cell migration ,morphogenesis of a branching structure , neuron migration , cell activation , vasculature development , reproductive developmental process , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , cellular ion homeostasis , cellular calcium ion homeostasis , cellular metal ion homeostasis , apoptosis , cell motion , chemotaxis , defense response , inflammatory response , immune response , cell surface receptor linked signal transduction , G-protein coupled receptor protein signaling pathway , elevation of cytosolic calcium ion concentration ,intracellular signaling cascade , protein kinase cascade , gamete generation , germ cell development , pattern specification process , axonogenesis , axon guidance , behavior , locomotory behavior , motor axon guidance , cell death ,cell proliferation , germ cell migration , response to wounding , response to virus , programmed cell death , viral reproduction , death , phosphorylation , cell migration , viral infectious cycle , initiation of viral infection , regulation of phosphate metabolic process , cellular homeostasis , sexual reproduction , viral reproductive process , cellular cation homeostasis , cellular di- , tri-valent inorganic cation homeostasis , cell projection organization , neuron differentiation ,regulation of cell migration , neuron projection development , multicellular organism reproduction , mononuclear cell proliferation , cellular component morphogenesis , cell part morphogenesis , positive regulation of kinase activity , tube morphogenesis , tube development , regulation of locomotion , T cell proliferation , T cell activation , regulation of phosphorylation , taxis , homeostatic process , positive regulation of catalytic activity , regulation of MAP kinase activity ,positive regulation of MAP kinase activity , regulation of kinase activity , positive regulation of molecular function ,leukocyte activation , regulation of protein kinase activity , positive regulation of protein kinase activity , lymphocyte activation , lymphocyte proliferation , blood vessel morphogenesis , reproductive process in a multicellular organism ,reproductive cellular process , neuron development , cell morphogenesis involved in neuron differentiation , branching morphogenesis of a tube , neuron projection morphogenesis , cell projection morphogenesis , cell motility , chemical homeostasis , ion homeostasis , regulation of phosphorus metabolic process , regulation of cell motion , regulation of transferase activity , positive regulation of transferase activity , cytosolic calcium ion homeostasis , localization of cell ,metal ion homeostasis , di- , tri-valent inorganic cation homeostasis , calcium ion homeostasis , cation homeostasis ,cellular chemical homeostasis , response to oxygen levels , leukocyte proliferation ,

Cell membrane ; Multi-pass membrane protein . Cell junction. Early endosome. Late endosome. Lysosome. In unstimulated cells , diffuse pattern on plasma membrane. On agonist stimulation , colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen , distributes to the immunological synapse forming at the T-cell-APC contact area , where it localizes at the peripheral and distal supramolecular activation cluster (SMAC) .