F3

Tissue factor ;
TF ;
Coagulation factor III ;
Thromboplastin ;
CD antigen CD142 ;

function:Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. ,induction:TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF , as well as by endotoxin , to appear on monocytes and vascular endothelial cells as a component of cellular immune response. ,online information:The Singapore human mutation and polymorphism database ,online information:Tissue factor entry ,similarity:Belongs to the tissue factor family. ,

regulation of endothelial cell proliferation , positive regulation of endothelial cell proliferation , acute inflammatory response , activation of plasma proteins involved in acute inflammatory response , activation of blood coagulation via clotting cascade , proteolysis , apoptosis , anti-apoptosis , activation of caspase activity , defense response , inflammatory response , blood coagulation , blood coagulation , extrinsic pathway , hemostasis , cell death , positive regulation of cell proliferation , response to wounding , positive regulation of signal transduction , regulation of protein kinase cascade ,regulation of platelet-derived growth factor receptor signaling pathway , positive regulation of platelet-derived growth factor receptor signaling pathway , positive regulation of cell communication , positive regulation of protein kinase cascade , regulation of cell death , positive regulation of peptidase activity , programmed cell death , death , protein processing , regulation of blood coagulation , positive regulation of blood coagulation , regulation of cell migration ,positive regulation of cell migration , regulation of response to external stimulus , positive regulation of response to external stimulus , regulation of locomotion , positive regulation of locomotion , wound healing , regulation of cell proliferation , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , positive regulation of catalytic activity , positive regulation of caspase activity ,regulation of caspase activity , positive regulation of molecular function , regulation of angiogenesis , positive regulation of angiogenesis , positive regulation of behavior , positive regulation of response to stimulus , regulation of behavior ,coagulation , regulation of coagulation , positive regulation of coagulation , regulation of body fluid levels , regulation of chemotaxis , positive regulation of chemotaxis , regulation of positive chemotaxis , positive regulation of positive chemotaxis , positive regulation of developmental process , positive regulation of multicellular organismal process ,regulation of cell motion , positive regulation of cell motion , regulation of hydrolase activity , positive regulation of hydrolase activity , protein maturation , protein maturation by peptide bond cleavage , regulation of protein kinase B signaling cascade , positive regulation of protein kinase B signaling cascade , regulation of peptidase activity , regulation of endopeptidase activity , negative regulation of cell death ,

[Isoform 1]: Membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .