ERK 3 (Phospho Ser189) Cell-Based Colorimetric ELISA Kit
-KA1457C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
ERK 3 Rabbit pAb
YT1628
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Primary Antibodies
ERK 3 (Phospho Ser189) Rabbit pAb
YP0738
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ELISA Kits
Total ERK 3 Cell-Based Colorimetric ELISA Kit
KA3769C
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ELISA Kits
ERK 3 (Phospho Ser189) Cell-Based Colorimetric ELISA Kit
KA1457C
预览→
抗原&靶点信息
基因名称:
MAPK6
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蛋白名称:
Mitogen-activated protein kinase 6
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别名:
Mitogen-activated protein kinase 6 ;
MAP kinase 6 ;
MAPK 6 ;
Extracellular signal-regulated kinase 3 ;
ERK-3 ;
MAP kinase isoform p97 ;
p97-MAPK ;
MAP kinase 6 ;
MAPK 6 ;
Extracellular signal-regulated kinase 3 ;
ERK-3 ;
MAP kinase isoform p97 ;
p97-MAPK ;
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背景:
The protein encoded by this gene is a member of the Ser/Thr protein kinase family , and is most closely related to mitogen-activated protein kinases (MAP kinases) . MAP kinases also known as extracellular signal-regulated kinases (ERKs) , are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus , and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq , Jul 2008] ,
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功能:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,Domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. ,enzyme regulation:Activated by threonine and tyrosine phosphorylation. ,Function:Phosphorylates microtubule-associated protein 2 (MAP2) . May promote entry in the cell cycle. ,PTM:Dually phosphorylated on Thr-626 and Tyr-628 , which activates the enzyme. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,tissue specificity:Highest expression in the skeletal muscle , followed by the brain. Also found in heart , placenta , lung , liver , pancreas , kidney and skin fibroblasts. ,
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细胞定位:
Cytoplasm . Nucleus . Translocates to the cytoplasm following interaction with MAPKAPK5. .
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