CALM1

Calmodulin ;
CaM ;

function:Calmodulin mediates the control of a large number of enzymes and other proteins by Ca (2+) . Among the enzymes to be stimulated by the calmodulin-Ca (2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin , is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. ,miscellaneous:This protein has four functional calcium-binding sites. ,PTM:Phosphorylation results in a decreased activity. ,PTM:Ubiquitination results in a strongly decreased activity. ,similarity:Belongs to the calmodulin family. ,similarity:Contains 4 EF-hand domains. ,subcellular location:Distributed throughout the cell during interphase , but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. ,subunit:Interacts with MYO1C (By similarity) . Interacts with CEP97 , CEP110 , TTN/titin and SRY. ,

cell cycle , cell surface receptor linked signal transduction , G-protein coupled receptor protein signaling pathway ,response to inorganic substance , response to metal ion , regulation of calcium ion transport into cytosol , regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum , regulation of metal ion transport , regulation of transmembrane transporter activity , regulation of intracellular transport , regulation of transporter activity , negative regulation of transporter activity , positive regulation of transporter activity , regulation of ion transmembrane transporter activity , negative regulation of ion transmembrane transporter activity , positive regulation of ion transmembrane transporter activity , regulation of cytokinesis , regulation of homeostatic process , regulation of transmembrane transport , regulation of ion transmembrane transport , regulation of ion transport , positive regulation of DNA binding , negative regulation of molecular function , positive regulation of molecular function , positive regulation of transport , negative regulation of transport , regulation of binding , positive regulation of binding , regulation of DNA binding , regulation of release of sequestered calcium ion into cytosol , regulation of cell division , response to calcium ion , regulation of calcium ion transport , regulation of ryanodine-sensitive calcium-release channel activity , negative regulation of ryanodine-sensitive calcium-release channel activity , positive regulation of ryanodine-sensitive calcium-release channel activity , regulation of cellular localization ,