详细信息
推荐稀释比
WB 1:500-2000
组成
Liquid in PBS
来源
E.coli
纯度
SDS-PAGE >90%
储存
-20°C/6 month,-80°C for long storage
相关产品
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
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Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
预览→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
预览→
抗原&靶点信息
序列:
Amino acid: 22-120, with his-MBP tag.
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基因名称:
HSPA8
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蛋白名称:
HSC70 protein
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别名:
Heat shock cognate 71 kDa protein ;
Heat shock 70 kDa protein 8 ;
Heat shock 70 kDa protein 8 ;
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背景:
function:Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.,induction:Constitutively synthesized.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Interacts with PACRG and TSC2. Interacts with SV40 VP1.,tissue specificity:Ubiquitous.,
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功能:
protein folding, 'de novo' protein folding, post-Golgi vesicle-mediated transport, response to unfolded protein,response to organic substance, membrane organization, vesicle-mediated transport, intracellular transport, Golgi vesicle transport, 'de novo' posttranslational protein folding, chaperone mediated protein folding requiring cofactor,regulation of cell cycle, response to protein stimulus,
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细胞定位:
Cytoplasm. Melanosome. Nucleus, nucleolus. Cell membrane. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Translocates rapidly from the cytoplasm to the nuclei, and especially to the nucleoli, upon heat shock.
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组织表达:
Ubiquitous.
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信号通路
Organismal Systems >> Immune system >> Antigen processing and presentation
Organismal Systems >> Endocrine system >> Estrogen signaling pathway
Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Human Diseases >> Neurodegenerative disease >> Prion disease
Environmental Information Processing >> Signal transduction >> MAPK signaling pathway
Genetic Information Processing >> Folding, sorting and degradation >> Protein processing in endoplasmic reticulum
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