PTP1B (Phospho Ser50) Cell-Based Colorimetric ELISA Kit
-KA1416C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
PTP1B Rabbit pAb
YT3900
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Primary Antibodies
PTP1B (Phospho Ser50) Rabbit pAb
YP0722
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ELISA Kits
Total PTP1B Cell-Based Colorimetric ELISA Kit
KA4257C
预览→
ELISA Kits
PTP1B (Phospho Ser50) Cell-Based Colorimetric ELISA Kit
KA1416C
预览→
抗原&靶点信息
基因名称:
PTPN1
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别名:
Tyrosine-protein phosphatase non-receptor type 1 ;
Protein-tyrosine phosphatase 1B ;
PTP-1B ;
Protein-tyrosine phosphatase 1B ;
PTP-1B ;
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背景:
catalytic activity:Protein tyrosine phosphate + H (2) O = protein tyrosine + phosphate. ,function:May play an important role in CKII- and p60c-src-induced signal transduction cascades. ,PTM:Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link , triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction. ,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. ,similarity:Contains 1 tyrosine-protein phosphatase domain. ,
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功能:
protein amino acid dephosphorylation , phosphorus metabolic process , phosphate metabolic process , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , insulin receptor signaling pathway , response to endogenous stimulus ,response to hormone stimulus , negative regulation of signal transduction , response to organic substance , negative regulation of cell communication , dephosphorylation , response to insulin stimulus , cellular response to insulin stimulus ,cellular response to hormone stimulus , response to peptide hormone stimulus , regulation of insulin receptor signaling pathway , negative regulation of insulin receptor signaling pathway , negative regulation of response to stimulus ,
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细胞定位:
Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Interacts with EPHA3 at the cell membrane.
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信号通路
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