PRKCE

Protein kinase C epsilon type ;
nPKC-epsilon ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,domain:The C1 domain , containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B) , is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain. ,enzyme regulation:Three specific sites; Thr-566 (activation loop of the kinase domain) , Thr-710 (turn motif) and Ser-729 (hydrophobic region) , need to be phosphorylated for its full activation. ,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters , a class of tumor promoters. ,function:This is calcium-independent , phospholipid-dependent , serine- and threonine-specific enzyme. ,PTM:Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. ,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. ,similarity:Contains 1 AGC-kinase C-terminal domain. ,similarity:Contains 1 C2 domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers. ,subunit:Forms a ternary complex with TRIM63 and GN2BL1. ,

regulation of protein amino acid phosphorylation , protein amino acid phosphorylation , phosphorus metabolic process ,phosphate metabolic process , induction of apoptosis , intracellular signaling cascade , regulation of cell death , positive regulation of cell death , induction of programmed cell death , phosphorylation , regulation of phosphate metabolic process , regulation of protein modification process , regulation of cellular protein metabolic process , regulation of phosphorylation , regulation of apoptosis , positive regulation of apoptosis , regulation of programmed cell death ,positive regulation of programmed cell death , regulation of peptidyl-tyrosine phosphorylation , regulation of phosphorus metabolic process ,

Cytoplasm . Cytoplasm , cytoskeleton . Cell membrane . Cytoplasm , perinuclear region . Nucleus . Translocated to plasma membrane in epithelial cells stimulated by HGF (PubMed:17603037) . Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity) . In passaging cells , translocated to the cell periphery (By similarity) . Translocated to the nucleus in PMA-treated cells (By similarity) . .