Amino acid: 342-428, with his-MBP tag.

BECN1

Beclin-1 protein

Beclin-1 ;
Coiled-coil myosin-like BCL2-interacting protein ;
Protein GT197 ;

function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous.,

autophagic vacuole formation, autophagy, anti-apoptosis, defense response, cellular defense response, vacuole organization, negative regulation of cell proliferation, cellular response to starvation, response to virus, regulation of catabolic process, positive regulation of catabolic process, response to extracellular stimulus, regulation of autophagy,positive regulation of autophagy, positive regulation of cell communication, regulation of cell death, macroautophagy,positive regulation of macroautophagy, regulation of macroautophagy, regulation of cellular catabolic process, positive regulation of cellular catabolic process, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, regulation of response to external stimulus, positive regulation of response to external stimulus, regulation of response to extracellular stimulus, positive regulation of response to extracellular stimulus,regulation of response to nutrient levels, positive regulation of response to nutrient levels, cellular response to stress,regulation of cell proliferation, response to starvation, regulation of apoptosis, negative regulation of apoptosis,regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of response to stimulus, negative regulation of cell death, regulation of cellular response to stress,

Cytoplasm . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). .; [Beclin-1-C 35 kDa]: Mitochondrion . Nucleus . Cytoplasm .; [Beclin-1-C 37 kDa]: Mitochondrion .

Ubiquitous.