GAB1

GRB2-associated-binding protein 1 ;
GRB2-associated binder 1 ;
Growth factor receptor bound protein 2-associated protein 1 ;

function:Probably involved in EGF and insulin receptor signaling. ,PTM:Phosphorylated on tyrosine residue (s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) . Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. ,similarity:Belongs to the GAB family. ,similarity:Contains 1 PH domain. ,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. ,

MAPKKK cascade , activation of MAPK activity , regulation of protein amino acid phosphorylation , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , response to oxidative stress , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , epidermal growth factor receptor signaling pathway , intracellular signaling cascade , protein kinase cascade , JNK cascade , activation of JUN kinase activity , cell proliferation , insulin receptor signaling pathway , response to endogenous stimulus , response to hormone stimulus , response to organic substance , regulation of protein kinase cascade , phosphorylation , regulation of phosphate metabolic process ,regulation of cell migration , stress-activated protein kinase signaling pathway , regulation of protein modification process , regulation of cellular protein metabolic process , response to insulin stimulus , cellular response to insulin stimulus , cellular response to hormone stimulus , cellular response to stress , positive regulation of kinase activity ,regulation of locomotion , regulation of phosphorylation , positive regulation of catalytic activity , regulation of MAP kinase activity , positive regulation of MAP kinase activity , regulation of MAPKKK cascade , response to peptide hormone stimulus , regulation of JUN kinase activity , positive regulation of JUN kinase activity , regulation of kinase activity ,positive regulation of molecular function , regulation of protein kinase activity , positive regulation of protein kinase activity , regulation of JNK cascade , regulation of phosphorus metabolic process , regulation of cell motion , regulation of transferase activity , positive regulation of transferase activity , regulation of stress-activated protein kinase signaling pathway , regulation of cellular response to stress ,