BCR

Breakpoint cluster region protein ;
Renal carcinoma antigen NY-REN-26 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,disease:A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t (9;22) (q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) . ,domain:The DH domain is involved in interaction with CCPG1. ,domain:The region involved in binding to ABL1 SH2-domain is rich in serine residues and needs to be Ser/Thr phosphorylated prior to SH2 binding. This region is essential for the activation of the ABL1 tyrosine kinase and transforming potential of the chimeric BCR-ABL oncogene. ,function:GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP , thereby activating them. Displays serine/threonine kinase activity. ,PTM:Autophosphorylated. ,similarity:Contains 1 C2 domain. ,similarity:Contains 1 DH (DBL-homology) domain. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 Rho-GAP domain. ,subunit:Homotetramer. Interacts with PDZK1. May interact with CCPG1. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , intracellular signaling cascade , phosphorylation , regulation of Rho protein signal transduction , regulation of Ras protein signal transduction , regulation of small GTPase mediated signal transduction ,

Cell junction , synapse , postsynaptic density . Cell projection , dendritic spine . Cell projection , axon . Cell junction , synapse .