ALOX5 (Phospho Ser271) Cell-Based Colorimetric ELISA Kit
-KA1396C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
5-LO Rabbit pAb
YT0027
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Primary Antibodies
5-LO (Phospho Ser272) Rabbit pAb
YP0715
预览→
Primary Antibodies
5-LO (Phospho Ser523) Rabbit pAb
YP0491
预览→
ELISA Kits
Total ALOX5 Cell-Based Colorimetric ELISA Kit
KA3993C
预览→
ELISA Kits
ALOX5 (Phospho Ser271) Cell-Based Colorimetric ELISA Kit
KA1396C
预览→
抗原&靶点信息
基因名称:
ALOX5
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别名:
Arachidonate 5-lipoxygenase ;
5-LO ;
5-lipoxygenase ;
5-LO ;
5-lipoxygenase ;
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背景:
catalytic activity:Arachidonate + O (2) = leukotriene A (4) + H (2) O. ,cofactor:Binds 1 iron ion per subunit. ,cofactor:Binds 2 calcium ions per subunit. ,function:Catalyzes the first step in leukotriene biosynthesis , and thereby plays a role in inflammatory processes. ,pathway:Lipid metabolism; leukotriene A4 biosynthesis. ,PTM:Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-523 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus. ,similarity:Belongs to the lipoxygenase family. ,similarity:Contains 1 lipoxygenase domain. ,similarity:Contains 1 PLAT domain. ,subcellular location:Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus , when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association. ,subunit:Interacts with ALOX5AP and LTC4S. ,
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功能:
very-long-chain fatty acid metabolic process , fatty acid metabolic process , fatty acid biosynthetic process , unsaturated fatty acid biosynthetic process , icosanoid metabolic process , leukotriene metabolic process , defense response ,inflammatory response , response to nutrient , lipid biosynthetic process , response to wounding , response to extracellular stimulus , organic acid biosynthetic process , regulation of vasoconstriction , leukotriene biosynthetic process , response to nutrient levels , unsaturated fatty acid metabolic process , cellular alkene metabolic process ,alkene biosynthetic process , regulation of system process , positive regulation of vasoconstriction , carboxylic acid biosynthetic process , icosanoid biosynthetic process , positive regulation of multicellular organismal process , oxidation reduction ,
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细胞定位:
Cytoplasm . Nucleus matrix . Nucleus membrane ; Peripheral membrane protein . Cytoplasm , perinuclear region . Cytoplasm , cytosol . Nucleus envelope . Nucleus intermembrane space . Shuttles between cytoplasm and nucleus (PubMed:19233132) . Found exclusively in the nucleus , when phosphorylated on Ser-272 (PubMed:18978352) . Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association (PubMed:19233132 , PubMed:3118366 , PubMed:8245774 , PubMed:16275640) . .
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