ADRB2

Beta-2 adrenergic receptor ;
Beta-2 adrenoreceptor ;
Beta-2 adrenoceptor ;

disease:Polymorphic forms of ADRB2 could impart some form of nocturnal asthma. ,function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. ,PTM:Palmitoylated; may reduce accessibility of Ser-345 and Ser-346 by anchoring Cys-341 to the plasma membrane. Agonist stimulation promotes depalmitoylation and further allows Ser-345 and Ser-346 phosphorylation. ,PTM:Phosphorylated by PKA and BARK upon agonist stimulation , which mediates homologous desensitization of the receptor. PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK. Phosphorylated upon DNA damage , probably by ATM or ATR. ,PTM:Phosphorylation of Tyr-141 is induced by insulin and leads to supersensitization of the receptor. ,similarity:Belongs to the G-protein coupled receptor 1 family. ,subunit:Binds SLC9A3R1 and GPRASP1. ,

temperature homeostasis , tissue homeostasis , regulation of systemic arterial blood pressure by norepinephrine-epinephrine , response to dietary excess , diet induced thermogenesis , vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure , regulation of sodium ion transport , desensitization of G-protein coupled receptor protein signaling pathway , desensitization of G-protein coupled receptor protein signaling pathway by arrestin , circulatory system process , vascular process in circulatory system , regulation of systemic arterial blood pressure mediated by a chemical signal , regulation of systemic arterial blood pressure , negative regulation of systemic arterial blood pressure , regulation of nucleotide metabolic process , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , protein complex assembly , endocytosis ,receptor-mediated endocytosis , regulation of muscle contraction , regulation of smooth muscle contraction , vacuolar transport , lysosomal transport , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , activation of transmembrane receptor protein tyrosine kinase activity , G-protein coupled receptor protein signaling pathway , G-protein signaling , coupled to cyclic nucleotide second messenger , G-protein signaling , coupled to cAMP nucleotide second messenger ,activation of adenylate cyclase activity by G-protein signaling pathway , activation of adenylate cyclase activity ,intracellular signaling cascade , blood circulation , regulation of heart contraction , regulation of blood pressure ,regulation of G-protein coupled receptor protein signaling pathway , positive regulation of cell proliferation , endosome to lysosome transport , response to temperature stimulus , response to cold , response to abiotic stimulus , positive regulation of biosynthetic process , positive regulation of signal transduction , negative regulation of signal transduction , membrane invagination , positive regulation of macromolecule biosynthetic process , regulation of adenylate cyclase activity involved in G-protein signaling , positive regulation of adenylate cyclase activity by G-protein signaling pathway , positive regulation of macromolecule metabolic process , regulation of protein kinase cascade ,positive regulation of gene expression , positive regulation of cell communication , negative regulation of cell communication , positive regulation of protein kinase cascade , positive regulation of sodium ion transport , regulation of cell death , positive regulation of cell death , regulation of metal ion transport , membrane organization , vesicle-mediated transport , endosome transport , regulation of striated muscle tissue development , regulation of phosphate metabolic process , second-messenger-mediated signaling , cAMP-mediated signaling , cyclic-nucleotide-mediated signaling , adaptation of signaling pathway , regulation of transmembrane transporter activity , regulation of ossification , negative regulation of ossification , regulation of bone mineralization , positive regulation of bone mineralization , regulation of cyclic nucleotide metabolic process , regulation of cyclic nucleotide biosynthetic process ,regulation of nucleotide biosynthetic process , regulation of cAMP metabolic process , regulation of cAMP biosynthetic process , regulation of cyclase activity , positive regulation of cyclase activity , positive regulation of cellular biosynthetic process , negative regulation of defense response , regulation of neurological system process , heat generation ,negative regulation of protein binding , regulation of response to external stimulus , negative regulation of response to external stimulus , activation of protein kinase activity , regulation of transporter activity , negative regulation of transporter activity , regulation of ion transmembrane transporter activity , negative regulation of ion transmembrane transporter activity , positive regulation of kinase activity , cellular macromolecular complex subunit organization ,cellular macromolecular complex assembly , regulation of transmembrane transport , regulation of ion transmembrane transport , regulation of tube size , regulation of growth , regulation of multicellular organism growth , negative regulation of multicellular organism growth , regulation of cell proliferation , vasodilation , regulation of vasodilation ,regulation of phosphorylation , homeostatic process , regulation of apoptosis , positive regulation of apoptosis ,regulation of programmed cell death , positive regulation of programmed cell death , positive regulation of catalytic activity , regulation of potassium ion transport , positive regulation of potassium ion transport , regulation of ion transport , positive regulation of ion transport , negative regulation of ion transport , regulation of protein binding ,regulation of MAPKKK cascade , positive regulation of MAPKKK cascade , regulation of kinase activity , cellular protein complex assembly , macromolecular complex subunit organization , regulation of system process , negative regulation of molecular function , positive regulation of molecular function , regulation of multicellular organismal metabolic process ,positive regulation of multicellular organismal metabolic process , fat cell differentiation , regulation of transcription ,bone resorption , negative regulation of G-protein coupled receptor protein signaling pathway , regulation of adenylate cyclase activity , positive regulation of adenylate cyclase activity , negative regulation of blood pressure , positive regulation of ossification , positive regulation of heart contraction , positive regulation of striated muscle development ,regulation of protein kinase activity , positive regulation of protein kinase activity , positive regulation of transcription , DNA-dependent , positive regulation of vasodilation , negative regulation of growth , positive regulation of growth ,negative regulation of muscle contraction , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , negative regulation of smooth muscle contraction , bone remodeling , intracellular transport , negative regulation of response to stimulus , regulation of skeletal muscle growth , positive regulation of skeletal muscle growth ,regulation of muscle development , positive regulation of muscle development , regulation of developmental growth ,positive regulation of developmental growth , regulation of skeletal muscle tissue development , positive regulation of skeletal muscle tissue development , tissue remodeling , multicellular organismal homeostasis , regulation of inflammatory response , negative regulation of inflammatory response , brown fat cell differentiation , regulation of blood vessel size , positive regulation of transport , negative regulation of transport , positive regulation of developmental process , regulation of binding , negative regulation of binding , positive regulation of nitrogen compound metabolic process , regulation of phosphorus metabolic process , positive regulation of multicellular organismal process ,negative regulation of multicellular organismal process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , regulation of transferase activity , regulation of lyase activity , positive regulation of transferase activity , positive regulation of lyase activity , regulation of calcium ion transport , regulation of calcium ion transport via voltage-gated calcium channel activity , negative regulation of calcium ion transport , negative regulation of calcium ion transport via voltage-gated calcium channel activity , regulation of sensory perception of pain , regulation of sensory perception , anatomical structure homeostasis , macromolecular complex assembly , regulation of biomineral formation ,positive regulation of biomineral formation , protein complex biogenesis ,

Cell membrane ; Multi-pass membrane protein . Early endosome . Golgi apparatus . Colocalizes with VHL at the cell membrane (PubMed:19584355) . Activated receptors are internalized into endosomes prior to their degradation in lysosomes (PubMed:20559325) . Activated receptors are also detected within the Golgi apparatus (PubMed:27481942) . .