YAP (Phospho Ser127) Cell-Based Colorimetric ELISA Kit
-KA1392C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
YAP Rabbit pAb
YT4924
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Primary Antibodies
YAP (Phospho Ser127) Rabbit pAb
YP0708
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ELISA Kits
Total YAP Cell-Based Colorimetric ELISA Kit
KA3612C
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ELISA Kits
YAP (Phospho Ser127) Cell-Based Colorimetric ELISA Kit
KA1392C
预览→
抗原&靶点信息
基因名称:
YAP1
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别名:
Yorkie homolog ;
65 kDa Yes-associated protein ;
YAP65 ;
65 kDa Yes-associated protein ;
YAP65 ;
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背景:
PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Contains 1 WW domain. ,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds , in vitro , through the WW1 domain , to neural isoforms of ENAH that contain the PPSY motif. ,
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功能:
regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , positive regulation of biosynthetic process , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , positive regulation of cellular biosynthetic process , regulation of transcription , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process ,
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细胞定位:
Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288 , PubMed:20048001) . Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288 , PubMed:20048001) . At low density , predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288 , PubMed:20048001 , PubMed:25849865) . PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271) . Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity) . .
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信号通路
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