PEA15

Astrocytic phosphoprotein PEA-15 ;
15 kDa phosphoprotein enriched in astrocytes ;
Phosphoprotein enriched in diabetes ;
PED ;

function:Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity) . Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. ,PTM:Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones. ,similarity:Contains 1 DED (death effector) domain. ,subcellular location:Associated with microtubules. ,subunit:Binds RPS6KA3 , MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity) . Interacts with CASP8 and FADD. ,tissue specificity:Ubiquitously expressed. Most abundant in tissues such as heart , brain , muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. ,

apoptosis , anti-apoptosis , cell death , carbohydrate transport , regulation of glucose transport , negative regulation of glucose transport , regulation of cell death , programmed cell death , death , regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , negative regulation of programmed cell death , regulation of glucose import , negative regulation of glucose import , negative regulation of transport , negative regulation of cell death ,

Cytoplasm. Associated with microtubules.