MAPK14

Mitogen-activated protein kinase 14 ;
MAP kinase 14 ;
MAPK 14 ;
Cytokine suppressive anti-inflammatory drug-binding protein ;
CSAID-binding protein ;
CSBP ;
MAP kinase MXI2 ;
MAX-interacting protein 2 ;
Mitogen-activated protein kinase p38 alpha ;
MAP kinase p38 alpha ;
Stress-activated protein kinase 2a ;
SAPK2a ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. ,enzyme regulation:Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases , MAP2K3 or MAP2K6 , and potentially also MAP2K4. Inhibited by dual specificity phosphatases , such as DUSP1. Specifically inhibited by the binding of pyridinyl-imidazole compounds , which are cytokine-suppressive anti-inflammatory drugs (CSAID) . Isoform Mxi2 is 100-fold less sensitive to these agents than the other isoforms and is not inhibited by DUSP1. Isoform Exip is not activated by MAP2K6. ,function:Responds to activation by environmental stress , pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors , such as ELK1 and ATF2 and several downstream kinases , such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines , for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis. ,online information:P38 mitogen-activated protein kinases entry ,PTM:Dually phosphorylated on Thr-180 and Tyr-182 , which activates the enzyme. ,PTM:Phosphorylated upon DNA damage , probably by ATM or ATR. ,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. ,similarity:Contains 1 protein kinase domain. ,subunit:Binds to a kinase interaction motif within the protein tyrosine phosphatase , PTPRR. This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation. Interacts with SPAG9 (By similarity) . Interacts with NP60 and FAM48A. ,tissue specificity:Brain , heart , placenta , pancreas and skeletal muscle. Expressed to a lesser extent in lung , liver and kidney. ,

cell cycle checkpoint , DNA damage checkpoint , skeletal system development , angiogenesis , blood vessel development ,vasculature development , chondrocyte differentiation , response to molecule of bacterial origin , monosaccharide metabolic process , glucose metabolic process , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , protein amino acid phosphorylation , fatty acid metabolic process , phosphorus metabolic process , phosphate metabolic process , cell motion , chemotaxis , response to DNA damage stimulus , cell surface receptor linked signal transduction , intracellular signaling cascade , protein kinase cascade , small GTPase mediated signal transduction , Ras protein signal transduction , muscle organ development , skeletal muscle tissue development , behavior , locomotory behavior , response to bacterium , positive regulation of biosynthetic process ,response to organic substance , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , striated muscle tissue development ,phosphorylation , hexose metabolic process , fatty acid oxidation , lipid modification , positive regulation of cellular biosynthetic process , DNA integrity checkpoint , lipopolysaccharide-mediated signaling pathway , response to peptidoglycan , response to muramyl dipeptide , response to lipopolysaccharide , regulation of homeostatic process ,cellular response to stress , lipid oxidation , taxis , DNA damage response , signal transduction , regulation of transcription , positive regulation of cell differentiation , regulation of myeloid cell differentiation , positive regulation of myeloid cell differentiation , regulation of erythrocyte differentiation , positive regulation of erythrocyte differentiation ,positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , blood vessel morphogenesis , positive regulation of developmental process , positive regulation of nitrogen compound metabolic process , cartilage development , regulation of RNA metabolic process ,positive regulation of RNA metabolic process , regulation of cell cycle , muscle tissue development , skeletal muscle organ development ,

Cytoplasm . Nucleus .