BCAR1

Breast cancer anti-estrogen resistance protein 1 ;
CRK-associated substrate ;
Cas scaffolding protein family member 1 ;
p130cas ;

domain:A serine-rich region promotes activation of the serum response element (SRE) . ,domain:Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK , NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with CASL. ,domain:The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of focal adhesion kinase 1. ,function:Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. ,PTM:Focal adhesion kinase 1 phosphorylates the protein at the YDYVHL motif. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix. ,similarity:Belongs to the CAS family. ,similarity:Contains 1 SH3 domain. ,subcellular location:Unphosphorylated form localizes in the cytoplasm and can move to the membrane upon tyrosine phosphorylation. ,subunit:Forms complexes in vivo with focal adhesion kinase 1 , adapter protein CRKL and LYN kinase. Can heterodimerize with CASL. Interacts with BCAR3 , NPHP1 , PTK2B and SH2D3C (By similarity) . Interacts with activated CSPG4. Interacts with INPPL1/SHIP2. ,tissue specificity:Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver , thymus , and peripheral blood leukocytes. The protein has been detected in a B-cell line. ,

regulation of cell growth , activation of immune response , immune response-activating cell surface receptor signaling pathway , positive regulation of immune system process , immune response-activating signal transduction , immune response-regulating signal transduction , immune response-regulating cell surface receptor signaling pathway , cell motion , cytoskeleton organization , actin filament organization , cell adhesion , cell surface receptor linked signal transduction , enzyme linked receptor protein signaling pathway , transmembrane receptor protein tyrosine kinase signaling pathway , epidermal growth factor receptor signaling pathway , G-protein coupled receptor protein signaling pathway , integrin-mediated signaling pathway , cell proliferation , insulin receptor signaling pathway , response to endogenous stimulus , response to hormone stimulus , response to organic substance , regulation of cell death , cell migration , biological adhesion , actin filament-based process , actin cytoskeleton organization , regulation of cell migration , positive regulation of cell migration , response to insulin stimulus , cellular response to insulin stimulus ,cellular response to hormone stimulus , regulation of growth , regulation of locomotion , positive regulation of locomotion , regulation of apoptosis , regulation of programmed cell death , response to peptide hormone stimulus ,platelet-derived growth factor receptor signaling pathway , nerve growth factor receptor signaling pathway , positive regulation of response to stimulus , cell motility , positive regulation of immune response , antigen receptor-mediated signaling pathway , T cell receptor signaling pathway , B cell receptor signaling pathway , regulation of cell motion ,positive regulation of cell motion , cell division , localization of cell ,

Cell junction , focal adhesion . Cytoplasm . Cell projection , axon . Unphosphorylated form localizes in the cytoplasm (By similarity) . Localizes to focal adhesion sites following integrin engagement (By similarity) . .