GRIN1

Glutamate [NMDA] receptor subunit zeta-1 ;
N-methyl-D-aspartate receptor subunit NR1 ;
NMD-R1 ;

function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity , synaptogenesis , excitotoxicity , memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. ,online information:NMDA receptor entry ,PTM:NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB) . Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity. ,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family. ,subcellular location:Enriched in post-synaptic plasma membrane and post-synaptic densities. ,subunit:Forms heteromeric channel of a zeta subunit (GRIN1) , a epsilon subunit (GRIN2A , GRIN2B , GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B) ; disulfide-linked. Found in a complex with GRIN2A or GRIN2B , GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ. ,

conditioned taste aversion , startle response , suckling behavior , response to amphetamine , regulation of transcription , DNA-dependent , regulation of transcription from RNA polymerase II promoter , ion transport , cation transport , calcium ion transport , cellular ion homeostasis , cellular calcium ion homeostasis , cellular metal ion homeostasis , cell surface receptor linked signal transduction , glutamate signaling pathway , cell-cell signaling , synaptic transmission , nerve-nerve synaptic transmission , sensory perception , behavior , learning or memory , learning , memory , long-term memory ,mating behavior , mating , locomotory behavior , feeding behavior , visual behavior , chemosensory behavior , associative learning , adult locomotory behavior , olfactory learning , visual learning , response to radiation , response to light stimulus , response to abiotic stimulus , response to endogenous stimulus , positive regulation of biosynthetic process ,response to organic substance , response to organic nitrogen , positive regulation of macromolecule biosynthetic process , positive regulation of macromolecule metabolic process , positive regulation of gene expression , regulation of cell morphogenesis involved in differentiation , regulation of cell death , positive regulation of cell death , regulation of neuron projection development , response to organic cyclic substance , response to isoquinoline alkaloid , response to amine stimulus , di- , tri-valent inorganic cation transport , reproductive behavior , transmission of nerve impulse ,sensory perception of pain , cellular homeostasis , telencephalon development , pallium development , pons development , hindbrain maturation , pons maturation , central nervous system maturation , developmental maturation ,cerebral cortex development , metencephalon development , regulation of cell morphogenesis , metal ion transport ,cellular cation homeostasis , cellular di- , tri-valent inorganic cation homeostasis , adult behavior , forebrain development ,hindbrain development , positive regulation of cellular biosynthetic process , regulation of cell projection organization ,regulation of neurological system process , regulation of response to external stimulus , negative regulation of response to external stimulus , multicellular organism reproduction , reproductive behavior in a multicellular organism ,social behavior , ionotropic glutamate receptor signaling pathway , synaptic transmission , glutamatergic , olfactory behavior , regulation of membrane potential , homeostatic process , regulation of apoptosis , positive regulation of apoptosis , negative regulation of apoptosis , regulation of programmed cell death , positive regulation of programmed cell death , negative regulation of programmed cell death , response to morphine , response to alkaloid , regulation of neuron apoptosis , negative regulation of neuron apoptosis , regulation of respiratory gaseous exchange , regulation of system process , regulation of cellular component biogenesis , regulation of transcription , response to ethanol ,regulation of neuron differentiation , positive regulation of transcription , DNA-dependent , positive regulation of nucleobase , nucleoside , nucleotide and nucleic acid metabolic process , positive regulation of transcription , positive regulation of transcription from RNA polymerase II promoter , regulation of synaptic plasticity , regulation of neuronal synaptic plasticity , regulation of long-term neuronal synaptic plasticity , negative regulation of response to stimulus ,reproductive process in a multicellular organism , regulation of dendrite morphogenesis , chemical homeostasis ,regulation of neurogenesis , regulation of axonogenesis , regulation of dendrite development , ion homeostasis ,regulation of synapse structure and activity , regulation of synaptic transmission , regulation of synapse organization ,neurological system process , cognition , neuromuscular process , positive regulation of nitrogen compound metabolic process , regulation of RNA metabolic process , positive regulation of RNA metabolic process , behavioral interaction between organisms , membrane depolarization , regulation of nervous system development , regulation of synaptogenesis , regulation of transmission of nerve impulse , metal ion homeostasis , di- , tri-valent inorganic cation homeostasis , calcium ion homeostasis , cation homeostasis , cellular chemical homeostasis , regulation of postsynaptic membrane potential , regulation of excitatory postsynaptic membrane potential , prepulse inhibition , male mating behavior , regulation of cell development , negative regulation of cell death ,

Cell membrane ; Multi-pass membrane protein . Cell junction , synapse , postsynaptic cell membrane . Cell junction , synapse , postsynaptic density . Enriched in postsynaptic plasma membrane and postsynaptic densities. .