STK3/STK4

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,cofactor:Magnesium. ,enzyme regulation:Inhibited by the C-terminal non-catalytic region. Activated by caspase-cleavage. Full activation also requires homodimerization and autophosphorylation of Thr-180 , which are inhibited by the proto-oncogene product RAF1. ,function:Stress-activated , pro-apoptotic kinase which , following caspase-cleavage , enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Phosphorylates NKX2-1 (By similarity) . Phosphorylates and activates LATS1 and LATS2. ,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SARAH domain. ,subcellular location:The caspase-cleaved form cycles between nucleus and cytoplasm. ,subunit:Homodimer; mediated via the coiled-coil region. Interacts with NORE1 , which inhibits autoactivation (By similarity) . Interacts with and stabilizes SAV1. Interacts with RAF1 , which prevents dimerization and phosphorylation. Interacts with RASSF1 , which leads to enzyme activation. ,tissue specificity:Expressed at high levels in adult kidney , skeletal and placenta tissues and at very low levels in adult heart , lung and brain tissues. ,

protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , apoptosis ,intracellular signaling cascade , protein kinase cascade , cell death , regulation of cell death , positive regulation of cell death , programmed cell death , death , phosphorylation , regulation of apoptosis , positive regulation of apoptosis ,regulation of programmed cell death , positive regulation of programmed cell death ,

Cytoplasm . Nucleus . The caspase-cleaved form cycles between nucleus and cytoplasm (PubMed:19525978 , PubMed:11278283) . Phosphorylation at Thr-117 leads to inhibition of nuclear translocation (PubMed:19525978) . .