ATRIP (Phospho Ser68) Cell-Based Colorimetric ELISA Kit
-KA1398C
主要信息
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
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ATRIP (Phospho Ser68) Cell-Based Colorimetric ELISA Kit
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抗原&靶点信息
基因名称:
ATRIP
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别名:
ATR-interacting protein ;
ATM and Rad3-related-interacting protein ;
ATM and Rad3-related-interacting protein ;
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背景:
caution:The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame. ,domain:The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage. ,function:Required for checkpoint signaling after DNA damage. Required for ATR expression , possibly by stabilizing the protein. ,PTM:Phosphorylated by ATR. ,sequence caution:Translation N-terminally extended. ,similarity:Belongs to the ATRIP family. ,subcellular location:Redistributes to discrete nuclear foci upon DNA damage. ,subunit:Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus) . ,tissue specificity:Ubiquitous. ,
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功能:
cell cycle checkpoint , DNA damage checkpoint , DNA metabolic process , DNA replication , DNA repair , response to DNA damage stimulus , intracellular signaling cascade , DNA integrity checkpoint , cellular response to stress , DNA damage response , signal transduction , regulation of cell cycle ,
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细胞定位:
Nucleus . Redistributes to discrete nuclear foci upon DNA damage.
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组织表达:
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