MAPKAPK2

MAP kinase-activated protein kinase 2 ;
MAPK-activated protein kinase 2 ;
MAPKAP kinase 2 ;
MAPKAP-K2 ;
MAPKAPK-2 ;
MK-2 ;
MK2 ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein. ,enzyme regulation:Seems to be activated by two distinct pathways: the first involves the stimulation of p42/p44 MAPK by growth factors , the second , triggered by stress and heat shock , depends on the activation of MPK2 and upstream MAPKK/MAPKKK. ,function:Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25) . In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40') . This kinase phosphorylates Ser in the peptide sequence , Hyd-X-R-X (2) -S , where Hyd is a large hydrophobic residue (By similarity) . Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity. ,PTM:Phosphorylated and activated by MAP kinase. ,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. ,similarity:Contains 1 protein kinase domain. ,subunit:Interacts with PHC2. ,tissue specificity:Expressed in all tissues examined. ,

MAPKKK cascade , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process ,intracellular signaling cascade , protein kinase cascade , small GTPase mediated signal transduction , Ras protein signal transduction , posttranscriptional regulation of gene expression , mRNA metabolic process , phosphorylation , regulation of RNA stability , regulation of mRNA stability , RNA stabilization , mRNA stabilization , regulation of RNA metabolic process ,

Cytoplasm . Nucleus . Phosphorylation and subsequent activation releases the autoinhibitory helix , resulting in the export from the nucleus into the cytoplasm.