ETK (Phospho Tyr40) Cell-Based Colorimetric ELISA Kit
-KA1364C
主要信息
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
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抗原&靶点信息
基因名称:
BMX
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别名:
Cytoplasmic tyrosine-protein kinase BMX ;
Bone marrow tyrosine kinase gene in chromosome X protein ;
Epithelial and endothelial tyrosine kinase ;
ETK ;
NTK38 ;
Bone marrow tyrosine kinase gene in chromosome X protein ;
Epithelial and endothelial tyrosine kinase ;
ETK ;
NTK38 ;
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背景:
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,cofactor:Binds 1 zinc ion per subunit. ,domain:SH2 domain mediates interaction with RUFY1. ,function:Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells. ,induction:Activated by IL-6 through phosphatidylinositol 3-kinase (PI3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the PH domain. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. ,similarity:Contains 1 Btk-type zinc finger. ,similarity:Contains 1 PH domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH2 domain. ,subunit:Interacts with RUFY1 and RUFY2. ,tissue specificity:Preferentially expressed in epithelial and endothelial cells. ,
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功能:
protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , intracellular signaling cascade , mesoderm development , phosphorylation ,
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细胞定位:
Cytoplasm . Localizes to the edges of spreading cells when complexed with BCAR1.
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