ACK1 (Phospho Tyr284) Cell-Based Colorimetric ELISA Kit
-KA1352C
主要信息
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Phospho
详细信息
储存
2-8°C/6 months,Ship by ice bag
修饰
Phospho
检测方法
Colorimetric
相关产品
Primary Antibodies
ACK1 Rabbit pAb
YT5018
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Primary Antibodies
ACK1 (Phospho Tyr284) Rabbit pAb
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ELISA Kits
Total ACK1 Cell-Based Colorimetric ELISA Kit
KA3986C
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ELISA Kits
ACK1 (Phospho Tyr284) Cell-Based Colorimetric ELISA Kit
KA1352C
预览→
抗原&靶点信息
基因名称:
TNK2 ACK1
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别名:
TNK2 ;
ACK1 ;
Activated CDC42 kinase 1 ;
ACK-1 ;
Tyrosine kinase non-receptor protein 2
ACK1 ;
Activated CDC42 kinase 1 ;
ACK-1 ;
Tyrosine kinase non-receptor protein 2
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背景:
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. ,cofactor:Magnesium. ,enzyme regulation:The SH3 domain appears to play an autoinhibitory role. ,function:Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR. Participates in clathrin-mediated endocytosis. May be involved both in adult synaptic function and plasticity and in brain development. ,sequence caution:Unlikely isoform. Aberrant splice sites. ,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ,similarity:Contains 1 CRIB domain. ,similarity:Contains 1 protein kinase domain. ,similarity:Contains 1 SH3 domain. ,subunit:Interacts with CDC42. Interacts with activated CSPG4. ,
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功能:
regulation of protein amino acid phosphorylation , positive regulation of protein amino acid phosphorylation , protein amino acid phosphorylation , phosphorus metabolic process , phosphate metabolic process , intracellular signaling cascade , small GTPase mediated signal transduction , positive regulation of phosphorus metabolic process , positive regulation of macromolecule metabolic process , phosphorylation , regulation of phosphate metabolic process ,regulation of protein modification process , positive regulation of protein modification process , regulation of cellular protein metabolic process , positive regulation of cellular protein metabolic process , regulation of phosphorylation ,positive regulation of phosphorylation , positive regulation of phosphate metabolic process , regulation of peptidyl-tyrosine phosphorylation , positive regulation of peptidyl-tyrosine phosphorylation , regulation of phosphorus metabolic process , positive regulation of protein metabolic process ,
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细胞定位:
Cell membrane . Nucleus . Endosome . Cell junction , adherens junction . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side . Cytoplasmic vesicle , clathrin-coated vesicle . Membrane , clathrin-coated pit . Cytoplasm , perinuclear region . Cytoplasm , cytosol . The Tyr-284 phosphorylated form is found both in the membrane and nucleus (By similarity) . Co-localizes with EGFR on endosomes (PubMed:20333297) . Nuclear translocation is CDC42-dependent (By similarity) . Detected in long filamentous cytosolic structures where it co-localizes with CTPS1 (By similarity) . .
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